|
gptkbp:instanceOf
|
gptkb:antibiotic
peptide
|
|
gptkbp:ATCCode
|
D06AX01
|
|
gptkbp:CASNumber
|
113-73-5
|
|
gptkbp:category
|
antimicrobial peptide
antibiotic for topical use
nonribosomal peptide
|
|
gptkbp:chemicalFormula
|
C60H92N12O10
|
|
gptkbp:compatibleWith
|
systemic infections
|
|
gptkbp:containsAminoAcid
|
gptkb:D-phenylalanine
gptkb:L-ornithine
gptkb:L-leucine
L-proline
L-valine
|
|
gptkbp:discoveredBy
|
G.A. Gause
|
|
gptkbp:discoveredIn
|
1944
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Gramicidin S
|
|
gptkbp:mechanismOfAction
|
disrupts bacterial cell membranes
|
|
gptkbp:meltingPoint
|
~250°C (decomposes)
|
|
gptkbp:molecularWeight
|
1141.45 g/mol
|
|
gptkbp:notEffectiveAgainst
|
Gram-negative bacteria
|
|
gptkbp:producedBy
|
gptkb:Bacillus_brevis
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1201202
441356
|
|
gptkbp:relatedTo
|
Gramicidin A
Tyrocidine
|
|
gptkbp:routeOfAdministration
|
topical
|
|
gptkbp:sideEffect
|
allergic reaction
skin irritation
|
|
gptkbp:solubility
|
slightly soluble in water
soluble in methanol
|
|
gptkbp:spectrumOfActivity
|
Gram-positive bacteria
|
|
gptkbp:structure
|
cyclic decapeptide
|
|
gptkbp:toxicity
|
hemolytic to human cells
|
|
gptkbp:UNII
|
8U7I4V6E6M
|
|
gptkbp:usedFor
|
topical treatment of infections
|
|
gptkbp:bfsParent
|
gptkb:1GRI
|
|
gptkbp:bfsLayer
|
7
|