|
gptkbp:instanceOf
|
gptkb:dementia
Neurodegenerative disease
|
|
gptkbp:affects
|
frontal lobes
temporal lobes
|
|
gptkbp:alsoKnownAs
|
gptkb:FTD
|
|
gptkbp:associatedWith
|
gptkb:GRN
gptkb:C9orf72
gptkb:MAPT
|
|
gptkbp:averageSurvivalAfterDiagnosis
|
6-8 years
|
|
gptkbp:cause
|
genetic mutations
abnormal protein aggregates
|
|
gptkbp:commonIn
|
middle-aged adults
|
|
gptkbp:diagnosedBy
|
clinical assessment
neuroimaging
genetic testing
|
|
gptkbp:differentialDiagnosis
|
gptkb:Alzheimer's_disease
psychiatric disorders
|
|
gptkbp:firstDescribed
|
gptkb:Arnold_Pick
1892
|
|
gptkbp:hasNoCure
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Frontotemporal Dementia
|
|
gptkbp:ICD-10_code
|
G31.0
|
|
gptkbp:MeSH_ID
|
D020961
|
|
gptkbp:mortalityRate
|
high
|
|
gptkbp:notableCase
|
Bruce Willis (reported diagnosis 2023)
|
|
gptkbp:OMIM
|
600274
|
|
gptkbp:onset
|
45-65 years
|
|
gptkbp:prevalence
|
second most common early-onset dementia
|
|
gptkbp:prognosis
|
progressive and fatal
|
|
gptkbp:progression
|
gradual
|
|
gptkbp:relatedTo
|
gptkb:Pick's_disease
|
|
gptkbp:riskFactor
|
family history
genetic predisposition
|
|
gptkbp:subspecies
|
gptkb:behavioral_variant_FTD
gptkb:primary_progressive_aphasia
gptkb:semantic_variant_PPA
nonfluent variant PPA
|
|
gptkbp:symptom
|
behavioral changes
apathy
personality changes
compulsive behavior
disinhibition
impaired executive function
language difficulties
|
|
gptkbp:treatment
|
supportive care
symptom management
|
|
gptkbp:bfsParent
|
gptkb:FUS
|
|
gptkbp:bfsLayer
|
5
|