Statements (20)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic disorder
|
| gptkbp:affects |
gptkb:EGFR_gene
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
gptkb:lung_adenocarcinoma |
| gptkbp:cause |
cancer cell proliferation
resistance to EGFR inhibitors |
| gptkbp:detects |
molecular testing
|
| gptkbp:discoveredIn |
2004
|
| gptkbp:grapeVariety |
gptkb:L858R
exon 19 deletion |
| https://www.w3.org/2000/01/rdf-schema#label |
EGFR mutation
|
| gptkbp:impact |
response to targeted therapy
|
| gptkbp:inheritance |
no (usually somatic)
|
| gptkbp:lessCommonVariant |
gptkb:T790M
exon 20 insertion |
| gptkbp:prevalence |
gptkb:Asian_populations
non-smokers with lung cancer |
| gptkbp:target |
tyrosine kinase inhibitors
|
| gptkbp:bfsParent |
gptkb:cancer
|
| gptkbp:bfsLayer |
4
|