Nav1.1 sodium channel

E874308

ion channel membrane protein voltage-gated sodium channel

The Nav1.1 sodium channel is a voltage-gated ion channel in neurons whose dysfunction is strongly implicated in severe epileptic disorders such as Dravet syndrome.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (7)

Label	Occurrences
NAv1.1 alpha subunit	1
NaV1.1	1
Nav1 family	1
Nav1.1 sodium channel canonical	1
SCN1A protein	1
Scn1a (mouse)	1
sodium channel protein type 1 subunit alpha	1

How this entity was disambiguated

This entity first appeared as the object of triple T10609957 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: Nav1.1 sodium channel
Context triple: [Dravet syndrome, affectsProtein, Nav1.1 sodium channel]

A. Opsanus tau
Opsanus tau, commonly known as the oyster toadfish, is a bottom-dwelling marine fish of the western Atlantic noted for its croaking sounds and ability to thrive in polluted, low-oxygen environments.
B. Lamaline
Lamaline is a small coastal town located on the Burin Peninsula in Newfoundland and Labrador, Canada, known historically for its fishing and maritime heritage.
C. Takic
Takic is a branch of the Uto-Aztecan language family comprising several closely related Indigenous languages historically spoken in Southern California.
D. Nutisal
Nutisal is a snack brand known for its range of dry-roasted and flavored nut products, owned by the Swedish confectionery company Cloetta.
E. Naux
Naux was a guitarist known for his work with the influential New York punk band Richard Hell and the Voidoids.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: Nav1.1 sodium channel
Target entity description: The Nav1.1 sodium channel is a voltage-gated ion channel in neurons whose dysfunction is strongly implicated in severe epileptic disorders such as Dravet syndrome.

A. Opsanus tau
Opsanus tau, commonly known as the oyster toadfish, is a bottom-dwelling marine fish of the western Atlantic noted for its croaking sounds and ability to thrive in polluted, low-oxygen environments.
B. Lamaline
Lamaline is a small coastal town located on the Burin Peninsula in Newfoundland and Labrador, Canada, known historically for its fishing and maritime heritage.
C. Takic
Takic is a branch of the Uto-Aztecan language family comprising several closely related Indigenous languages historically spoken in Southern California.
D. Nutisal
Nutisal is a snack brand known for its range of dry-roasted and flavored nut products, owned by the Swedish confectionery company Cloetta.
E. Naux
Naux was a guitarist known for his work with the influential New York punk band Richard Hell and the Voidoids.
F. None of above. chosen

Statements (49)

Predicate	Object
instanceOf	ion channel ⓘ membrane protein ⓘ voltage-gated sodium channel ⓘ
associatedWithDisease	Dravet syndrome ⓘ epileptic encephalopathy ⓘ familial hemiplegic migraine type 3 ⓘ febrile seizures ⓘ generalized epilepsy with febrile seizures plus ⓘ severe myoclonic epilepsy of infancy ⓘ
associatedWithPhenotype	temperature-sensitive seizures in Dravet syndrome ⓘ
belongsToFamily	Nav1 family ⓘ linked to: Nav1.1 sodium channel voltage-gated sodium channel alpha subunits ⓘ
chromosomalLocationOfGene	2q24.3 ⓘ
dysfunctionLeadsTo	network hyperexcitability ⓘ
dysfunctionMechanism	impaired firing of inhibitory interneurons ⓘ
encodedBy	SCN1A gene ⓘ linked to: SCN1A
expressedIn	central nervous system ⓘ
gatedBy	membrane voltage ⓘ
hasAlternativeName	NaV1.1 ⓘ linked to: Nav1.1 sodium channel Nav1.1 ⓘ SCN1A protein ⓘ linked to: Nav1.1 sodium channel
hasBiologicalProcess	action potential generation ⓘ regulation of neuronal excitability ⓘ synaptic transmission ⓘ
hasDomain	pore-forming domain ⓘ voltage-sensing domain ⓘ
hasFunction	initiates and propagates action potentials ⓘ mediates voltage-dependent sodium ion influx in neurons ⓘ
hasMolecularFunction	sodium ion transmembrane transporter activity ⓘ voltage-gated sodium channel activity ⓘ
hasSystematicName	sodium channel protein type 1 subunit alpha ⓘ linked to: SCN1A
hasTransmembraneSegments	four domains each with six transmembrane segments ⓘ
highlyExpressedIn	GABAergic inhibitory interneurons ⓘ
inactivatedBy	fast inactivation gate ⓘ
isTargetOf	antiepileptic drug research ⓘ
locatedIn	axon initial segment ⓘ neuronal plasma membrane ⓘ nodes of Ranvier ⓘ
mutationTypeAssociated	frameshift mutations ⓘ loss-of-function mutations ⓘ missense mutations ⓘ nonsense mutations ⓘ splice-site mutations ⓘ
orthologFoundIn	mouse ⓘ rat ⓘ zebrafish ⓘ linked to: Danio rerio
playsRoleIn	inhibitory neurotransmission ⓘ
selectiveFor	Na+ ions ⓘ
subunitComposition	alpha subunit with four homologous domains ⓘ

How these facts were elicited