catechol-O-methyltransferase
E804594
Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
All labels observed (3)
| Label | Occurrences |
|---|---|
| COMT | 1 |
| COMT (human) | 1 |
| catechol-O-methyltransferase canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9524773 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: catechol-O-methyltransferase Context triple: [levodopa, metabolizedBy, catechol-O-methyltransferase]
-
A.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
B.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
C.
MAO
MAO is a contemporary art gallery and exhibition space in Oxford, England, known for showcasing innovative modern and contemporary art.
-
D.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
-
E.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: catechol-O-methyltransferase Target entity description: Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
-
A.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
B.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
C.
MAO
MAO is a contemporary art gallery and exhibition space in Oxford, England, known for showcasing innovative modern and contemporary art.
-
D.
CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
-
E.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
- F. None of above. chosen
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
methyltransferase ⓘ transferase ⓘ |
| associatedWith |
cognitive function variation
ⓘ
pain sensitivity variation ⓘ risk of anxiety disorders ⓘ risk of schizophrenia ⓘ |
| biologicalProcess |
catecholamine catabolic process
ⓘ
dopamine catabolic process ⓘ epinephrine catabolic process ⓘ inactivation of catecholamine neurotransmitters ⓘ norepinephrine catabolic process ⓘ regulation of synaptic transmission ⓘ xenobiotic metabolic process ⓘ |
| catalyzesReaction | transfer of a methyl group from S-adenosyl-L-methionine to catechol substrates ⓘ |
| cellularLocation |
cytosol
ⓘ
plasma membrane ⓘ |
| chromosomalLocation | 22q11.21 (human COMT gene) ⓘ |
| drugTargetOf |
entacapone
ⓘ
opicapone ⓘ tolcapone ⓘ |
| encodedByGene |
COMT (human)
ⓘ
linked to:
catechol-O-methyltransferase
Comt (mouse) ⓘ Comt (rat) ⓘ |
| expressedInTissue |
blood cells
ⓘ
brain ⓘ intestinal tract ⓘ kidney ⓘ liver ⓘ |
| foundInOrganism |
Homo sapiens
ⓘ
Mus musculus ⓘ
linked to:
house mouse (Mus musculus)
Rattus norvegicus ⓘ
linked to:
Norway rat (Rattus norvegicus)
|
| hasECNumber | 2.1.1.6 ⓘ |
| hasGeneSymbol | COMT ⓘ |
| hasIsoform |
membrane-bound COMT
ⓘ
soluble COMT ⓘ |
| hasPolymorphism | Val158Met (rs4680) ⓘ |
| inhibitionUse | adjunct therapy in Parkinson’s disease ⓘ |
| modifiesMolecule |
L-DOPA
ⓘ
linked to:
levodopa
catechol estrogens ⓘ catecholamines ⓘ dopamine ⓘ epinephrine ⓘ norepinephrine ⓘ |
| molecularFunction |
S-adenosylmethionine-dependent methyltransferase activity
ⓘ
catechol O-methyltransferase activity ⓘ |
| pathway |
catecholamine metabolism
ⓘ
dopaminergic synapse ⓘ estrogen metabolism ⓘ |
| producesProduct | S-adenosyl-L-homocysteine ⓘ |
| usesCofactor | S-adenosyl-L-methionine ⓘ |
| Val158MetEffect | alters enzymatic activity and thermostability ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: catechol-O-methyltransferase Description of subject: Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: catechol-O-methyltransferase
linked to: catechol-O-methyltransferase