norepinephrine
E655337
Norepinephrine is a neurotransmitter and hormone involved in the body’s fight-or-flight response, regulating arousal, attention, and blood pressure.
All labels observed (2)
| Label | Occurrences |
|---|---|
| norepinephrine canonical | 3 |
| noradrenaline | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T7298289 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: norepinephrine Context triple: [Cocaine, affectsNeurotransmitter, norepinephrine]
-
A.
NAD
NAD is the three-letter ISO 4217 currency code for the Namibian dollar, the official currency of Namibia.
-
B.
ANP
ANP is the national police force of Afghanistan responsible for law enforcement, public order, and internal security across the country.
-
C.
Nut
Nut is the ancient Egyptian sky goddess, often depicted arching over the earth and associated with the heavens, stars, and the cyclical rebirth of the sun.
-
D.
Novafora
Novafora was a semiconductor company known for acquiring Transmeta to expand its presence in low-power microprocessor and video processing technologies.
-
E.
NER
NER is a commonly used abbreviation for Northeast India, a culturally diverse and geographically distinct region of the country comprising its easternmost states.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: norepinephrine Target entity description: Norepinephrine is a neurotransmitter and hormone involved in the body’s fight-or-flight response, regulating arousal, attention, and blood pressure.
-
A.
NAD
NAD is the three-letter ISO 4217 currency code for the Namibian dollar, the official currency of Namibia.
-
B.
ANP
ANP is the national police force of Afghanistan responsible for law enforcement, public order, and internal security across the country.
-
C.
Nut
Nut is the ancient Egyptian sky goddess, often depicted arching over the earth and associated with the heavens, stars, and the cyclical rebirth of the sun.
-
D.
Novafora
Novafora was a semiconductor company known for acquiring Transmeta to expand its presence in low-power microprocessor and video processing technologies.
-
E.
NER
NER is a commonly used abbreviation for Northeast India, a culturally diverse and geographically distinct region of the country comprising its easternmost states.
- F. None of above. chosen
Statements (71)
| Predicate | Object |
|---|---|
| instanceOf |
catecholamine
ⓘ
hormone ⓘ neurotransmitter ⓘ |
| actsOnReceptor |
alpha-1 adrenergic receptor
ⓘ
alpha-2 adrenergic receptor ⓘ beta-1 adrenergic receptor ⓘ |
| belongsToPathway |
adrenergic signaling pathway
ⓘ
catecholamine biosynthesis pathway ⓘ |
| bindsTo |
G protein-coupled receptors
ⓘ
linked to:
G protein–coupled receptors
|
| chemicalFormula | C8H11NO3 ⓘ |
| hasATCCode | C01CA03 ⓘ |
| hasCASNumber | 51-41-2 ⓘ |
| hasChirality | R-configuration at beta carbon ⓘ |
| hasFunctionalGroup |
alcohol
ⓘ
catechol ⓘ primary amine ⓘ |
| hasIUPACName | 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol ⓘ |
| hasLowAffinityFor | beta-2 adrenergic receptor ⓘ |
| hasMetabolite |
3-methoxy-4-hydroxyphenylglycol
ⓘ
MHPG ⓘ VMA ⓘ vanillylmandelic acid ⓘ |
| hasMolarMass | 169.18 g/mol ⓘ |
| hasOtherName |
(R)-(-)-norepinephrine
ⓘ
noradrenaline ⓘ
linked to:
norepinephrine
|
| haspKa | about 8.6 for amine group ⓘ |
| hasRouteOfAdministration | intravenous ⓘ |
| increases |
diastolic blood pressure
ⓘ
peripheral vascular resistance ⓘ systolic blood pressure ⓘ |
| isClearedBy |
NET
ⓘ
norepinephrine transporter ⓘ |
| isDerivedFrom | dopamine ⓘ |
| isEndogenousTo |
humans
ⓘ
mammals ⓘ |
| isHydrophilic | true ⓘ |
| isImplicatedIn |
ADHD
ⓘ
linked to:
attention-deficit/hyperactivity disorder
PTSD ⓘ attention-deficit hyperactivity disorder ⓘ depression ⓘ |
| isImplicatedIn | post-traumatic stress disorder ⓘ |
| isMetabolizedBy |
COMT
ⓘ
linked to:
catechol-O-methyltransferase
MAO-A ⓘ catechol-O-methyltransferase ⓘ monoamine oxidase ⓘ |
| isPartOf |
sympathetic nervous system
ⓘ
linked to:
Sympathetic nervous system
|
| isPolar | true ⓘ |
| isPrecursorOf | epinephrine ⓘ |
| isReleasedFrom |
adrenal medulla
ⓘ
locus coeruleus ⓘ sympathetic nerve terminals ⓘ |
| isStoredIn | synaptic vesicles ⓘ |
| isStoredWith |
ATP in vesicles
ⓘ
chromogranins in vesicles ⓘ |
| isSynthesizedByEnzyme | dopamine beta-hydroxylase ⓘ |
| isSynthesizedFrom |
L-DOPA
ⓘ
L-tyrosine ⓘ dopamine ⓘ |
| isUsedAs | vasopressor drug ⓘ |
| isUsedToTreat |
hypotension
ⓘ
septic shock ⓘ |
| mediates | fight-or-flight response ⓘ |
| modulates |
anxiety
ⓘ
mood ⓘ stress response ⓘ |
| regulates |
arousal
ⓘ
attention ⓘ blood pressure ⓘ heart rate ⓘ vascular tone ⓘ vigilance ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: norepinephrine Description of subject: Norepinephrine is a neurotransmitter and hormone involved in the body’s fight-or-flight response, regulating arousal, attention, and blood pressure.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: norepinephrine