CDK4
E561032
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
All labels observed (4)
| Label | Occurrences |
|---|---|
| cyclin-dependent kinase 4 | 2 |
| CDK4 canonical | 1 |
| CDK4 gene | 1 |
| cell division protein kinase 4 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6003524 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CDK4 Context triple: [Verzenio, targets, CDK4]
-
A.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
B.
CNK4
CNK4 is the ICAO airport code assigned to Parry Sound Area Municipal Airport in Ontario, Canada.
-
C.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
D.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
E.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CDK4 Target entity description: CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
A.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
B.
CNK4
CNK4 is the ICAO airport code assigned to Parry Sound Area Municipal Airport in Ontario, Canada.
-
C.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
D.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
E.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
- F. None of above. chosen
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
cyclin-dependent kinase
ⓘ
human gene ⓘ protein kinase ⓘ |
| alternativeName |
PSK-J3
ⓘ
cell division protein kinase 4 ⓘ
linked to:
CDK4
|
| associatedWithDisease |
breast cancer
ⓘ
glioblastoma ⓘ liposarcoma ⓘ melanoma ⓘ non-small cell lung cancer ⓘ |
| biologicalProcess |
G1 phase of mitotic cell cycle
ⓘ
G1/S transition of mitotic cell cycle ⓘ cell cycle checkpoint regulation ⓘ negative regulation of cell cycle arrest ⓘ phosphorylation of RB1 protein ⓘ regulation of cell proliferation ⓘ |
| cellularComponent |
cyclin-dependent protein kinase holoenzyme complex
ⓘ
cytoplasm ⓘ nucleus ⓘ |
| chromosomalBand | 12q14 ⓘ |
| clinicalBiomarkerRole | predictive biomarker for CDK4/6 inhibitor response ⓘ |
| conservedIn |
Danio rerio
ⓘ
Mus musculus ⓘ
linked to:
house mouse (Mus musculus)
Rattus norvegicus ⓘ
linked to:
Norway rat (Rattus norvegicus)
|
| encodedByGene |
CDK4 gene
ⓘ
linked to:
CDK4
|
| enzymeCommissionNumber | EC 2.7.11.22 ⓘ |
| formsComplexWith |
cyclin D1
ⓘ
cyclin D2 ⓘ cyclin D3 ⓘ |
| fullName |
cyclin-dependent kinase 4
ⓘ
linked to:
CDK4
|
| geneType | protein-coding gene ⓘ |
| hasEnsemblGeneID | ENSG00000135446 ⓘ |
| hasEntrezGeneID | 1019 ⓘ |
| hasHGNCID | HGNC:1773 ⓘ |
| hasUniProtID | P11802 ⓘ |
| inhibitedByDrug |
abemaciclib
ⓘ
linked to:
Verzenio
lenvatinib (weak off-target) ⓘ palbociclib ⓘ
linked to:
Ibrance
ribociclib ⓘ
linked to:
trilaciclib
trilaciclib ⓘ |
| locatedOnChromosome | human chromosome 12 ⓘ |
| molecularFunction |
ATP binding
ⓘ
cyclin-dependent protein serine/threonine kinase activity ⓘ serine/threonine protein kinase activity ⓘ |
| oncogenicMechanism |
activating mutation
ⓘ
gene amplification ⓘ overexpression ⓘ |
| organism | Homo sapiens ⓘ |
| pathway |
G1/S transition pathway
ⓘ
cell cycle pathway ⓘ p16INK4A-CDK4-RB pathway ⓘ |
| postTranslationalModification | phosphorylation at threonine 172 ⓘ |
| regulatedBy |
CDKN2A (p16INK4A)
ⓘ
CDKN2B (p15INK4B) ⓘ CDKN2C (p18INK4C) ⓘ CDKN2D (p19INK4D) ⓘ |
| requiresBindingPartner | D-type cyclins ⓘ |
| requiresCofactor | Mg2+ ⓘ |
| roleInCancerBiology |
drives cell cycle progression from G1 to S phase
ⓘ
promotes tumor cell proliferation when deregulated ⓘ |
| substrate |
RB1
ⓘ
RBL1 ⓘ RBL2 ⓘ |
| therapeuticTargetIn |
advanced breast cancer
ⓘ
hormone receptor-positive breast cancer ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CDK4 Description of subject: CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.