Cdc28
E556655
cell cycle regulator
cyclin-dependent kinase
protein kinase
protein-coding gene
serine/threonine protein kinase
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
All labels observed (4)
| Label | Occurrences |
|---|---|
| CDC28 gene | 1 |
| Cdc28 canonical | 1 |
| Cdc28p | 1 |
| Cdk1 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5931435 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Cdc28 Context triple: [Saccharomyces cerevisiae, cellCycleControlProtein, Cdc28]
-
A.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
B.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
C.
RAPC
RAPC is the abbreviation for the Royal Army Pay Corps, a former British Army administrative corps responsible for managing soldiers’ pay and financial services.
-
D.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
E.
CNK4
CNK4 is the ICAO airport code assigned to Parry Sound Area Municipal Airport in Ontario, Canada.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Cdc28 Target entity description: Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
A.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
B.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
C.
RAPC
RAPC is the abbreviation for the Royal Army Pay Corps, a former British Army administrative corps responsible for managing soldiers’ pay and financial services.
-
D.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
E.
CNK4
CNK4 is the ICAO airport code assigned to Parry Sound Area Municipal Airport in Ontario, Canada.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
cell cycle regulator
ⓘ
cyclin-dependent kinase ⓘ protein kinase ⓘ protein-coding gene ⓘ serine/threonine protein kinase ⓘ |
| activatedBy | cyclin binding ⓘ |
| cellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
| commonName |
Cdc28p
ⓘ
linked to:
Cdc28
|
| discoveredIn | cell division cycle mutant screens in yeast ⓘ |
| encodedBy |
CDC28 gene
ⓘ
linked to:
Cdc28
|
| essentialFor | viability of Saccharomyces cerevisiae ⓘ |
| formsComplexWith |
B-type cyclins
ⓘ
Clb1 ⓘ Clb2 ⓘ Clb3 ⓘ Clb4 ⓘ Clb5 ⓘ Clb6 ⓘ Cln1 ⓘ Cln2 ⓘ Cln3 ⓘ G1 cyclins ⓘ |
| hasBiologicalProcess |
DNA replication initiation
ⓘ
G1/S transition of mitotic cell cycle ⓘ G2/M transition of mitotic cell cycle ⓘ bud emergence ⓘ cell cycle ⓘ cell cycle checkpoint control ⓘ mating-type switching ⓘ mitosis ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
cyclin-dependent protein kinase activity ⓘ protein serine/threonine kinase activity ⓘ |
| organism | Saccharomyces cerevisiae ⓘ |
| orthologOf |
Cdk1
ⓘ
linked to:
Cdc28
|
| regulatedBy |
Cdc25 homolog Mih1
ⓘ
Cks1 ⓘ Far1 ⓘ Mih1 ⓘ Sic1 ⓘ Swe1 ⓘ phosphorylation ⓘ |
| requires | cyclin ⓘ |
| substrate |
Cdh1
ⓘ
Far1 ⓘ Sic1 ⓘ Whi5 ⓘ components of the pre-replicative complex ⓘ transcription factors regulating G1/S genes ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Cdc28 Description of subject: Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Cdc28
linked to: Cdc28