Yersinia outer proteins
E357721
Yersinia outer proteins are a group of effector proteins secreted by Yersinia bacteria via a type III secretion system that disrupt host immune responses and promote infection.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Yersinia outer proteins canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T3439042 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Yersinia outer proteins Context triple: [Yersinia pestis, virulenceFactor, Yersinia outer proteins]
-
A.
Gammaproteobacteria
Gammaproteobacteria is a major and diverse class of Gram-negative bacteria that includes many medically and ecologically important genera, such as Vibrio, Escherichia, and Pseudomonas.
-
B.
Nourse
Nourse is a surname and variant spelling of "Nurse," historically associated with English-speaking families and occasionally used as a place or business name.
-
C.
Yersinia pestis
Yersinia pestis is a highly virulent bacterium responsible for plague, including the historic pandemics of bubonic, septicemic, and pneumonic forms.
-
D.
Vibrio cholerae
Vibrio cholerae is a Gram-negative, comma-shaped bacterium that causes the acute diarrheal disease cholera in humans.
-
E.
Pyrobaculum aerophilum
Pyrobaculum aerophilum is a hyperthermophilic archaeon that thrives in extremely high-temperature, often sulfur-rich environments and serves as a model organism for studying the biology of Crenarchaeota.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Yersinia outer proteins Target entity description: Yersinia outer proteins are a group of effector proteins secreted by Yersinia bacteria via a type III secretion system that disrupt host immune responses and promote infection.
-
A.
Gammaproteobacteria
Gammaproteobacteria is a major and diverse class of Gram-negative bacteria that includes many medically and ecologically important genera, such as Vibrio, Escherichia, and Pseudomonas.
-
B.
Nourse
Nourse is a surname and variant spelling of "Nurse," historically associated with English-speaking families and occasionally used as a place or business name.
-
C.
Yersinia pestis
Yersinia pestis is a highly virulent bacterium responsible for plague, including the historic pandemics of bubonic, septicemic, and pneumonic forms.
-
D.
Vibrio cholerae
Vibrio cholerae is a Gram-negative, comma-shaped bacterium that causes the acute diarrheal disease cholera in humans.
-
E.
Pyrobaculum aerophilum
Pyrobaculum aerophilum is a hyperthermophilic archaeon that thrives in extremely high-temperature, often sulfur-rich environments and serves as a model organism for studying the biology of Crenarchaeota.
- F. None of above. chosen
Statements (43)
| Predicate | Object |
|---|---|
| instanceOf |
bacterial effector protein
ⓘ
type III secretion system effector ⓘ virulence factor ⓘ |
| alsoKnownAs | Yops ⓘ |
| component |
YopE
ⓘ
YopH ⓘ YopJ ⓘ YopK ⓘ YopM ⓘ YopN ⓘ YopO ⓘ YopP ⓘ YopQ ⓘ YopT ⓘ YpkA ⓘ |
| encodedBy | Yersinia virulence plasmid pYV ⓘ |
| function |
disrupt host immune responses
ⓘ
induce apoptosis in immune cells ⓘ inhibit inflammatory signaling pathways ⓘ inhibit phagocytosis ⓘ promote bacterial infection ⓘ |
| inhibitionOf |
MAPK signaling pathways
ⓘ
NF-kappaB signaling ⓘ phagocytic uptake by macrophages ⓘ pro-inflammatory cytokine production ⓘ |
| localization |
bacterial cytoplasm before secretion
ⓘ
host cell cytosol after translocation ⓘ |
| producedBy |
Yersinia
ⓘ
surface form:
Yersinia enterocolitica
Yersinia pestis ⓘ Yersinia ⓘ
surface form:
Yersinia pseudotuberculosis
|
| regulation |
induced at 37 degrees Celsius
ⓘ
induced upon host cell contact ⓘ |
| relevance |
potential targets for anti-virulence therapy
ⓘ
used as tools to study host signaling pathways ⓘ |
| roleInDisease |
gastroenteritis caused by Yersinia enterocolitica
ⓘ
mesenteric lymphadenitis ⓘ plague pathogenesis ⓘ |
| secretedBy | type III secretion system ⓘ |
| studiedIn |
immunology
ⓘ
infection biology ⓘ |
| target |
host adaptive immune system
ⓘ
host innate immune system ⓘ |
| transportMechanism | needle-like injectisome ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Yersinia outer proteins Description of subject: Yersinia outer proteins are a group of effector proteins secreted by Yersinia bacteria via a type III secretion system that disrupt host immune responses and promote infection.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.