Ionis Pharmaceuticals
E24882
Ionis Pharmaceuticals is a biotechnology company specializing in the discovery and development of RNA-targeted therapeutics using antisense technology.
All labels observed (6)
| Label | Occurrences |
|---|---|
| Ionis Pharmaceuticals canonical | 8 |
| Ionis Pharmaceuticals, Inc. | 2 |
| Akcea Therapeutics (historical affiliate) | 1 |
| Ionis antisense pipeline | 1 |
| Isis Pharmaceuticals | 1 |
| Isis Pharmaceuticals, Inc. | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T195393 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Ionis Pharmaceuticals Context triple: [Biogen, collaboratesWith, Ionis Pharmaceuticals]
-
A.
Biogen
Biogen is a major American biotechnology company known for developing therapies for neurological and neurodegenerative diseases.
-
B.
Genentech
Genentech is a pioneering American biotechnology company known for developing groundbreaking therapies and being one of the first firms to apply genetic engineering to medicine.
-
C.
ONR Global
ONR Global is the international arm of the U.S. Office of Naval Research that fosters and funds scientific collaboration and innovation with partners around the world to support naval and marine technologies.
-
D.
GlaxoSmithKline
GlaxoSmithKline is a global biopharmaceutical company known for developing and manufacturing prescription medicines, vaccines, and consumer healthcare products.
-
E.
Johnson & Johnson
Johnson & Johnson is a multinational healthcare conglomerate best known for its pharmaceuticals, medical devices, and consumer health products.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Ionis Pharmaceuticals Target entity description: Ionis Pharmaceuticals is a biotechnology company specializing in the discovery and development of RNA-targeted therapeutics using antisense technology.
-
A.
Biogen
Biogen is a major American biotechnology company known for developing therapies for neurological and neurodegenerative diseases.
-
B.
Genentech
Genentech is a pioneering American biotechnology company known for developing groundbreaking therapies and being one of the first firms to apply genetic engineering to medicine.
-
C.
ONR Global
ONR Global is the international arm of the U.S. Office of Naval Research that fosters and funds scientific collaboration and innovation with partners around the world to support naval and marine technologies.
-
D.
GlaxoSmithKline
GlaxoSmithKline is a global biopharmaceutical company known for developing and manufacturing prescription medicines, vaccines, and consumer healthcare products.
-
E.
Johnson & Johnson
Johnson & Johnson is a multinational healthcare conglomerate best known for its pharmaceuticals, medical devices, and consumer health products.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
biotechnology company
ⓘ
pharmaceutical company ⓘ public company ⓘ |
| aimsTo | treat diseases by targeting RNA ⓘ |
| basedIn |
California, United States
ⓘ
surface form:
California
|
| coDeveloped | Spinraza ⓘ |
| coDevelopedWith | Biogen ⓘ |
| country |
United States of America
ⓘ
surface form:
United States
|
| develops | antisense oligonucleotide drugs ⓘ |
| focusesOn |
cardiovascular diseases
ⓘ
metabolic diseases ⓘ neurological diseases ⓘ rare diseases ⓘ |
| formerName |
Ionis Pharmaceuticals
self-linksurface differs
ⓘ
surface form:
Isis Pharmaceuticals
|
| foundedBy | Stanley T. Crooke ⓘ |
| foundingYear | 1989 ⓘ |
| hasCollaborationWith |
AstraZeneca
ⓘ
Bayer ⓘ Biogen ⓘ GlaxoSmithKline ⓘ
surface form:
GSK
Novartis ⓘ Pfizer ⓘ Roche ⓘ |
| hasSubsidiaryOrAffiliate |
Ionis Pharmaceuticals
self-linksurface differs
ⓘ
surface form:
Akcea Therapeutics (historical affiliate)
|
| headquartersLocation |
Carlsbad
ⓘ
surface form:
Carlsbad, California, United States
|
| industry |
biotechnology
ⓘ
pharmaceuticals ⓘ |
| listedOn |
Nasdaq Biotechnology Index
ⓘ
surface form:
NASDAQ-100 Biotechnology Index
|
| notableProduct |
Spinraza
ⓘ
Tegsedi ⓘ Waylivra ⓘ |
| primaryBusinessModel | drug discovery and development ⓘ |
| regionServed | global ⓘ |
| researchArea |
cardiometabolic diseases
ⓘ
genetic diseases ⓘ neurodegenerative diseases ⓘ |
| revenueSource |
collaboration payments
ⓘ
licensing revenue ⓘ product sales ⓘ |
| specializesIn |
RNA-targeted therapeutics
ⓘ
antisense technology ⓘ |
| stockExchange | NASDAQ ⓘ |
| technologyPlatform | antisense oligonucleotide platform ⓘ |
| therapeuticApproach | RNA-targeted drug discovery ⓘ |
| tickerSymbol | IONS ⓘ |
| uses | antisense oligonucleotides to modulate RNA ⓘ |
| website | https://www.ionispharma.com ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Ionis Pharmaceuticals Description of subject: Ionis Pharmaceuticals is a biotechnology company specializing in the discovery and development of RNA-targeted therapeutics using antisense technology.
Referenced by (14)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Isis Pharmaceuticals
this entity surface form:
Akcea Therapeutics (historical affiliate)
this entity surface form:
Ionis Pharmaceuticals, Inc.
subject surface form:
Ionis Pharmaceuticals, Inc.
this entity surface form:
Isis Pharmaceuticals, Inc.