Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
scientific theory
|
| gptkbp:citation |
scientific literature on aging
|
| gptkbp:contrastsWith |
programmed aging theories
|
| gptkbp:describes |
role of DNA damage in aging
|
| gptkbp:field |
molecular biology
biogerontology |
| https://www.w3.org/2000/01/rdf-schema#label |
DNA damage theory of aging
|
| gptkbp:implies |
apoptosis
neurodegenerative diseases cellular senescence cancer risk increases with age tissue dysfunction |
| gptkbp:influencedBy |
environmental factors
oxidative stress mutagenic agents replication errors |
| gptkbp:proposedBy |
gptkb:Alexander_M._Olovnikov
gptkb:Bernard_L._Strehler DNA repair mechanisms decline with age accumulation of DNA damage causes aging genomic instability increases with age |
| gptkbp:relatedTo |
gptkb:free_radical_theory_of_aging
gptkb:somatic_mutation_theory_of_aging |
| gptkbp:studiedIn |
model organisms
|
| gptkbp:supportedBy |
evidence of increased DNA lesions in aged cells
|
| gptkbp:yearProposed |
1960s
|
| gptkbp:bfsParent |
gptkb:The_Mitochondrial_Free_Radical_Theory_of_Aging
|
| gptkbp:bfsLayer |
6
|