DB11799

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2020
gptkbp:ATCCode J05AB16
gptkbp:bioavailability low (IV only)
gptkbp:blackBoxWarning none
gptkbp:CASNumber 1809249-37-3
gptkbp:contraindication hypersensitivity to remdesivir
gptkbp:developer gptkb:Gilead_Sciences
gptkbp:drugClass antiviral drug
gptkbp:excretion renal
gptkbp:form solution for injection
lyophilized powder for injection
gptkbp:halfLife 1 hour (plasma)
gptkbp:hasBoxedWarning none
gptkbp:hasFirstApprovalCountry gptkb:United_States
gptkbp:hasFirstApprovalDate 2020-10-22
gptkbp:hasInChIKey RWWYLEGWBNMMLJ-YSOARWBDSA-N
gptkbp:hasLactationWarning unknown excretion in breast milk
gptkbp:hasMolecularFormula C27H35N6O8P
gptkbp:hasPatent US20150361013A1
gptkbp:hasPatentHolder gptkb:Gilead_Sciences
gptkbp:hasPharmacodynamics inhibits viral replication
gptkbp:hasPharmacokinetics rapidly distributed and metabolized
gptkbp:hasPregnancyCategoryUS Not assigned
gptkbp:hasPregnancyWarning use only if potential benefit justifies risk
gptkbp:hasSMILES CC(C)[C@@H](NC(=O)[C@@H](COP(=O)(OCC1=CN=CN1C)OCC2=CN(C3=CC=CC=C23)C)O)C(=O)N
gptkbp:hasStorageCondition store below 30°C
gptkbp:hasUNII 53J38M19LO
https://www.w3.org/2000/01/rdf-schema#label DB11799
gptkbp:indication gptkb:COVID-19
gptkb:Ebola_virus_infection
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction RNA polymerase inhibitor
gptkbp:metabolism hepatic
gptkbp:molecularWeight 602.6 g/mol
gptkbp:name gptkb:Remdesivir
gptkbp:pregnancyCategory Not assigned
gptkbp:PubChem_CID gptkb:DB11799
121304016
CHEMBL2016761
D11472
58191716
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
elevated liver enzymes
hypersensitivity
gptkbp:status FDA approved
EMA approved
gptkbp:structureType antiviral drug
gptkbp:synonym gptkb:GS-5734
gptkbp:target RNA-dependent RNA polymerase
gptkbp:bfsParent gptkb:D08513
gptkbp:bfsLayer 7