|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
keratin
|
|
gptkbp:antibodyTarget
|
gptkb:CK20
gptkb:CK7
gptkb:AE1/AE3
gptkb:CAM5.2
|
|
gptkbp:component
|
cytoskeleton
|
|
gptkbp:degradedBy
|
proteases
|
|
gptkbp:diagnosticUse
|
carcinoma identification
|
|
gptkbp:encodedBy
|
gptkb:KRT_genes
|
|
gptkbp:expressedIn
|
gptkb:skin
nails
hair
glands
mucosal surfaces
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:form
|
filamentous network
|
|
gptkbp:foundIn
|
epithelial cells
|
|
gptkbp:function
|
structural support
cell integrity
|
|
gptkbp:hasIsoform
|
gptkb:CK1
gptkb:CK20
gptkb:CK10
gptkb:CK14
gptkb:CK18
gptkb:CK19
gptkb:CK2
gptkb:CK5
gptkb:CK8
|
|
gptkbp:involvedIn
|
apoptosis
wound healing
cell migration
cell signaling
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
40-68 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:epidermolysis_bullosa_simplex
gptkb:pachyonychia_congenita
skin diseases
|
|
gptkbp:phosphorylates
|
gptkb:kinases
|
|
gptkbp:solubility
|
insoluble in water
|
|
gptkbp:stainingPattern
|
cytoplasmic
|
|
gptkbp:subclassOf
|
gptkb:intermediate_filament_protein
|
|
gptkbp:subspecies
|
gptkb:type_II_cytokeratin
gptkb:type_I_cytokeratin
|
|
gptkbp:usedAs
|
gptkb:biomarker
|
|
gptkbp:usedIn
|
pathology
cancer diagnosis
cancer prognosis
immunohistochemistry
biomarker research
differential diagnosis
|
|
gptkbp:usedToDistinguish
|
epithelial tumors
hematopoietic tumors
mesenchymal tumors
|
|
gptkbp:bfsParent
|
gptkb:CK
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytokeratin
|