Cytokeratin

GPTKB entity

Statements (57)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs keratin
gptkbp:antibodyTarget gptkb:CK20
gptkb:CK7
gptkb:AE1/AE3
gptkb:CAM5.2
gptkbp:component cytoskeleton
gptkbp:degradedBy proteases
gptkbp:diagnosticUse carcinoma identification
gptkbp:encodedBy gptkb:KRT_genes
gptkbp:expressedIn gptkb:skin
nails
hair
glands
mucosal surfaces
gptkbp:firstDescribed 1970s
gptkbp:form filamentous network
gptkbp:foundIn epithelial cells
gptkbp:function structural support
cell integrity
gptkbp:hasIsoform gptkb:CK1
gptkb:CK20
gptkb:CK10
gptkb:CK14
gptkb:CK18
gptkb:CK19
gptkb:CK2
gptkb:CK5
gptkb:CK8
https://www.w3.org/2000/01/rdf-schema#label Cytokeratin
gptkbp:involvedIn apoptosis
wound healing
cell migration
cell signaling
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight 40-68 kDa
gptkbp:mutationAssociatedWith gptkb:epidermolysis_bullosa_simplex
gptkb:pachyonychia_congenita
skin diseases
gptkbp:phosphorylates gptkb:kinases
gptkbp:solubility insoluble in water
gptkbp:stainingPattern cytoplasmic
gptkbp:subclassOf intermediate filament protein
gptkbp:subspecies gptkb:type_II_cytokeratin
gptkb:type_I_cytokeratin
gptkbp:usedAs biomarker
gptkbp:usedIn pathology
cancer diagnosis
cancer prognosis
immunohistochemistry
biomarker research
differential diagnosis
gptkbp:usedToDistinguish epithelial tumors
hematopoietic tumors
mesenchymal tumors
gptkbp:bfsParent gptkb:CK
gptkbp:bfsLayer 6