Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
gptkb:recombinase |
| gptkbp:catalyzes |
site-specific recombination
|
| gptkbp:discoveredBy |
Nat Sternberg
|
| gptkbp:EC_number |
2.7.0
|
| gptkbp:encodedBy |
P1 bacteriophage
|
| gptkbp:firstDescribed |
1981
|
| gptkbp:gene |
cre
|
| gptkbp:mechanismOfAction |
tyrosine recombinase
|
| gptkbp:molecularWeight |
38 kDa
|
| gptkbp:organismOfOrigin |
gptkb:bacteriophage_P1
|
| gptkbp:PDB |
1XO0
|
| gptkbp:recognizedBy |
loxP site
|
| gptkbp:sequenceSpecificity |
34 bp loxP site
|
| gptkbp:UniProtID |
P06956
|
| gptkbp:usedFor |
DNA excision
DNA inversion DNA translocation |
| gptkbp:usedIn |
gptkb:gene_therapy
gptkb:biotechnology gptkb:chromosomal_rearrangement cancer research developmental biology stem cell research synthetic biology plant genetics brain research genetic engineering genome editing molecular biology research Drosophila genetics mouse genetics zebrafish genetics transgenic animals inducible gene expression cell lineage tracing fate mapping Cre-Lox system cell ablation conditional gene activation conditional gene knockout conditional gene silencing conditional mutagenesis gene drive systems reporter gene activation transgene excision viral vector systems |
| gptkbp:bfsParent |
gptkb:SFM3_line
gptkb:Cre-ERT2_recombinase_systems gptkb:bacteriophage_P1 |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cre recombinase
|