Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
recombinase |
| gptkbp:catalyzes |
site-specific recombination
|
| gptkbp:discoveredBy |
Nat Sternberg
|
| gptkbp:EC_number |
2.7.0
|
| gptkbp:encodedBy |
P1 bacteriophage
|
| gptkbp:firstDescribed |
1981
|
| gptkbp:gene |
cre
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cre recombinase
|
| gptkbp:mechanismOfAction |
tyrosine recombinase
|
| gptkbp:molecularWeight |
38 kDa
|
| gptkbp:organismOfOrigin |
gptkb:bacteriophage_P1
|
| gptkbp:PDB |
1XO0
|
| gptkbp:recognizedBy |
loxP site
|
| gptkbp:sequenceSpecificity |
34 bp loxP site
|
| gptkbp:UniProtID |
P06956
|
| gptkbp:usedFor |
DNA excision
DNA inversion DNA translocation |
| gptkbp:usedIn |
gptkb:biotechnology
cancer research developmental biology stem cell research synthetic biology plant genetics brain research genetic engineering genome editing gene therapy molecular biology research Drosophila genetics mouse genetics zebrafish genetics transgenic animals inducible gene expression chromosomal rearrangement cell lineage tracing fate mapping Cre-Lox system cell ablation conditional gene activation conditional gene knockout conditional gene silencing conditional mutagenesis gene drive systems reporter gene activation transgene excision viral vector systems |
| gptkbp:bfsParent |
gptkb:SFM3_line
gptkb:Cre-ERT2_recombinase_systems gptkb:bacteriophage_P1 |
| gptkbp:bfsLayer |
8
|