Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:launch_complex
|
| gptkbp:bfsLayer |
4
|
| gptkbp:bfsParent |
gptkb:Golden_Eye_007
|
| gptkbp:associated_with |
FAD
|
| gptkbp:code |
SDHA, SDHB, SDHC, SDHD genes
|
| gptkbp:composed_of |
gptkb:Succinate_dehydrogenase
|
| gptkbp:established |
Succinate
Malonate |
| gptkbp:function |
Catalyzes the transfer of electrons from succinate to ubiquinone
|
| gptkbp:has_member |
Flavoprotein subunit
Iron-sulfur protein subunit |
| gptkbp:has_role |
Electron transport chain
|
| https://www.w3.org/2000/01/rdf-schema#label |
Complex 2
|
| gptkbp:interacts_with |
gptkb:Ubiquinone
|
| gptkbp:is_affected_by |
Environmental factors
|
| gptkbp:is_aimed_at |
Anticancer drugs
|
| gptkbp:is_associated_with |
Hypoxia
Reactive oxygen species production |
| gptkbp:is_critical_for |
Energy production
|
| gptkbp:is_essential_for |
Aerobic metabolism
|
| gptkbp:is_found_in |
Eukaryotic cells
|
| gptkbp:is_involved_in |
Apoptosis
Cell signaling Fatty acid metabolism Immune response Oxidative phosphorylation Cellular proliferation Cellular respiration Metabolic disorders Aging process Cellular stress response Cellular signaling pathways Hormonal regulation Metabolic pathways Amino acid metabolism Lipid metabolism Protein metabolism Cellular homeostasis Glucose metabolism Cellular differentiation Cellular repair mechanisms Cellular aging Nucleotide metabolism Cellular adaptation |
| gptkbp:is_linked_to |
Neurodegenerative diseases
Mitochondrial diseases Cancer metabolism |
| gptkbp:is_part_of |
Krebs cycle
Metabolic network Respiratory complex |
| gptkbp:is_related_to |
Mitochondrial dysfunction
|
| gptkbp:is_represented_in |
Heart tissue
Liver tissue Brain tissue |
| gptkbp:is_studied_in |
Biochemistry
Therapeutic targets |
| gptkbp:located_in |
Inner mitochondrial membrane
|
| gptkbp:part_of |
Mitochondrial respiratory chain
|
| gptkbp:produced_by |
Fumarate
|
| gptkbp:regulates |
NADH levels
|