Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:complex
|
| gptkbp:associated_with |
FAD
|
| gptkbp:code |
SDHA, SDHB, SDHC, SDHD genes
|
| gptkbp:composed_of |
gptkb:Succinate_dehydrogenase
|
| gptkbp:function |
Catalyzes the transfer of electrons from succinate to ubiquinone
|
| gptkbp:has_role |
Electron transport chain
|
| https://www.w3.org/2000/01/rdf-schema#label |
Complex 2
|
| gptkbp:initiated_by |
Succinate
Malonate |
| gptkbp:interacts_with |
gptkb:Ubiquinone
|
| gptkbp:involved_in |
Cellular respiration
|
| gptkbp:is_affected_by |
Environmental factors
|
| gptkbp:is_associated_with |
Hypoxia
Reactive oxygen species production |
| gptkbp:is_critical_for |
Energy production
|
| gptkbp:is_essential_for |
Aerobic metabolism
|
| gptkbp:is_expressed_in |
Heart tissue
Liver tissue Brain tissue |
| gptkbp:is_found_in |
Eukaryotic cells
|
| gptkbp:is_involved_in |
Apoptosis
Cell signaling Fatty acid metabolism Immune response Oxidative phosphorylation Cellular proliferation Metabolic disorders Aging process Cellular stress response Cellular signaling pathways Hormonal regulation Metabolic pathways Amino acid metabolism Lipid metabolism Protein metabolism Cellular homeostasis Glucose metabolism Cellular differentiation Cellular repair mechanisms Cellular aging Nucleotide metabolism Cellular adaptation |
| gptkbp:is_linked_to |
Neurodegenerative diseases
Mitochondrial diseases Cancer metabolism |
| gptkbp:is_part_of |
Krebs cycle
Metabolic network Respiratory complex |
| gptkbp:is_regulated_by |
NADH levels
|
| gptkbp:is_related_to |
Mitochondrial dysfunction
|
| gptkbp:is_studied_for |
Therapeutic targets
|
| gptkbp:is_studied_in |
Biochemistry
|
| gptkbp:is_targeted_at |
Anticancer drugs
|
| gptkbp:located_in |
Inner mitochondrial membrane
|
| gptkbp:part_of |
Mitochondrial respiratory chain
|
| gptkbp:produces |
Fumarate
|
| gptkbp:subunit |
Flavoprotein subunit
Iron-sulfur protein subunit |
| gptkbp:bfsParent |
gptkb:Golden_Eye_007
|
| gptkbp:bfsLayer |
6
|