|
gptkbp:instanceOf
|
gptkb:drug
alkaloid
|
|
gptkbp:ATCCode
|
M04AC01
|
|
gptkbp:brand
|
gptkb:Colcrys
Mitigare
|
|
gptkbp:CASNumber
|
64-86-8
|
|
gptkbp:chemicalFormula
|
C22H25NO6
|
|
gptkbp:contraindication
|
severe renal impairment
severe hepatic impairment
|
|
gptkbp:discoveredBy
|
gptkb:Pierre-Joseph_Pelletier
gptkb:Joseph_Bienaimé_Caventou
|
|
gptkbp:discoveredIn
|
1820
|
|
gptkbp:drugInteraction
|
CYP3A4 inhibitors
P-glycoprotein inhibitors
|
|
gptkbp:eliminationHalfLife
|
9 hours
|
|
gptkbp:excretion
|
gptkb:kidney
feces
|
|
gptkbp:foundIn
|
gptkb:autumn_crocus
|
|
gptkbp:hasAntimitoticEffect
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Colchicine
|
|
gptkbp:IUPACName
|
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
|
|
gptkbp:KEGGID
|
D00394
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:listedOn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:mechanismOfAction
|
inhibits microtubule polymerization
|
|
gptkbp:meltingPoint
|
155°C
|
|
gptkbp:MeSH_ID
|
D003073
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
399.437 g/mol
|
|
gptkbp:notRecommendedFor
|
children under 4 years
pregnant women (unless benefits outweigh risks)
|
|
gptkbp:originatedIn
|
gptkb:Colchicum_autumnale
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
6167
CHEMBL1070
|
|
gptkbp:riskFactor
|
muscular dystrophy
rhabdomyolysis
multi-organ failure (in overdose)
neuromuscular toxicity
toxicity in overdose
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
gastrointestinal upset
bone marrow suppression
|
|
gptkbp:UNII
|
SML2Y3J35T
|
|
gptkbp:usedFor
|
gptkb:familial_Mediterranean_fever
gout
|
|
gptkbp:usedIn
|
plant breeding (to induce polyploidy)
|
|
gptkbp:bfsParent
|
gptkb:Autumn_crocus
|
|
gptkbp:bfsLayer
|
6
|