Clorazepate

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
benzodiazepine
gptkbp:approvedBy gptkb:France
gptkbp:ATCCode N05BA05
gptkbp:availableOn potassium salt
gptkbp:brand Tranxene
gptkbp:CASNumber 23887-31-2
gptkbp:contraindication gptkb:myasthenia_gravis
acute narrow-angle glaucoma
severe respiratory insufficiency
sleep apnea syndrome
gptkbp:controlledSubstanceSchedule Schedule IV (US)
gptkbp:discoveredBy gptkb:Hoffmann-La_Roche
gptkbp:drugClass benzodiazepine
sedative
anticonvulsant
muscle relaxant
hypnotic
gptkbp:eliminationHalfLife 2 hours (parent), 20–179 hours (active metabolite)
gptkbp:excretion urine
gptkbp:hasActiveMetabolite nordazepam
gptkbp:hasINN clorazepate
gptkbp:hasMolecularFormula C16H11ClN2O3
gptkbp:hasSMILES C1C(=O)NC2=C(C=C(C=C2)Cl)C(=O)N1C3=CC=CC=C3
https://www.w3.org/2000/01/rdf-schema#label Clorazepate
gptkbp:introducedIn 1968
gptkbp:IUPACName 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction GABAA receptor positive allosteric modulator
gptkbp:metabolism desmethyldiazepam
gptkbp:pregnancyCategory gptkb:C_(Australia)
D (US)
gptkbp:prodrugOf nordazepam
gptkbp:proteinBinding 97%
gptkbp:PubChem_CID 2806
2704
gptkbp:riskOfDependence yes
gptkbp:riskOfWithdrawal yes
gptkbp:routeOfAdministration oral
gptkbp:sideEffect confusion
dizziness
fatigue
drowsiness
gptkbp:synonym clorazepate dipotassium
gptkbp:UNII U5V383OQ2O
gptkbp:usedFor gptkb:alcohol_withdrawal_syndrome
anxiety disorders
seizure disorders
gptkbp:bfsParent gptkb:N05BA
gptkbp:bfsLayer 7