Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:alsoKnownAs |
cellular senescence
|
| gptkbp:associatedWith |
oxidative stress
DNA damage telomere shortening epigenetic changes |
| gptkbp:canBeDelayedBy |
caloric restriction
telomerase activity |
| gptkbp:characterizedBy |
irreversible cell cycle arrest
|
| gptkbp:contributedTo |
age-related diseases
organismal aging |
| gptkbp:firstDescribed |
gptkb:Leonard_Hayflick
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cellular aging
|
| gptkbp:inducedBy |
radiation therapy
chemotherapy oncogene activation |
| gptkbp:occurredIn |
eukaryotic cells
|
| gptkbp:relatedTo |
gptkb:Hayflick_limit
apoptosis autophagy replicative senescence cellular quiescence |
| gptkbp:result |
altered cell function
secretion of inflammatory factors senescent cell accumulation |
| gptkbp:studiedIn |
gerontology
|
| gptkbp:bfsParent |
gptkb:Nucleolus
|
| gptkbp:bfsLayer |
7
|