|
gptkbp:instanceOf
|
gptkb:antineoplastic_agent
gptkb:implantable_medical_device
|
|
gptkbp:activeIngredient
|
gptkb:carmustine
|
|
gptkbp:administeredBy
|
surgical implantation
|
|
gptkbp:alternativeTo
|
systemic chemotherapy
|
|
gptkbp:approvedBy
|
gptkb:FDA
1996
|
|
gptkbp:ATCCode
|
L01AD01
|
|
gptkbp:brand
|
gptkb:Gliadel
|
|
gptkbp:contraindication
|
hypersensitivity to carmustine
recent brain surgery infection
|
|
gptkbp:deliversDrug
|
locally to tumor site
|
|
gptkbp:developedBy
|
Guilford Pharmaceuticals
|
|
gptkbp:form
|
biodegradable polymer wafer
|
|
gptkbp:indication
|
recurrent glioblastoma
newly diagnosed high-grade malignant glioma
|
|
gptkbp:isSolubleIn
|
brain tissue
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
gptkb:antineoplastic_agent
|
|
gptkbp:pregnancyCategory
|
D
|
|
gptkbp:routeOfAdministration
|
intracranial
|
|
gptkbp:sideEffect
|
seizures
wound healing complications
brain edema
intracranial infection
|
|
gptkbp:usedFor
|
treatment of brain tumors
treatment of glioblastoma multiforme
|
|
gptkbp:bfsParent
|
gptkb:High-grade_glioma
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Carmustine wafers
|