Calcium Release-Activated Calcium channel
GPTKB entity
Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
ion channel |
| gptkbp:activatedBy |
depletion of calcium in endoplasmic reticulum
|
| gptkbp:alsoKnownAs |
CRAC channel
|
| gptkbp:associatedWith |
STIM1
ORAI1 |
| gptkbp:component |
ORAI1 protein
STIM1 protein |
| gptkbp:discoveredBy |
gptkb:Roderick_MacKinnon
|
| gptkbp:dysregulationAssociatedWith |
immunodeficiency
Stormorken syndrome tubular aggregate myopathy |
| gptkbp:foundIn |
gptkb:plasma_membrane
immune cells |
| gptkbp:function |
mediates calcium influx
|
| https://www.w3.org/2000/01/rdf-schema#label |
Calcium Release-Activated Calcium channel
|
| gptkbp:inhibitedBy |
BTP2
Synta66 |
| gptkbp:requires |
mast cell degranulation
lymphocyte activation |
| gptkbp:role |
T cell activation
store-operated calcium entry |
| gptkbp:structure |
hexameric complex
|
| gptkbp:bfsParent |
gptkb:CRAC
|
| gptkbp:bfsLayer |
7
|