Calcitriol

URI: https://gptkb.org/entity/Calcitriol

GPTKB entity

Predicate	Object
gptkbp:instanceOf	hormone vitamin D metabolite
gptkbp:ATCCode	A11CC04
gptkbp:bioavailability	high
gptkbp:CASNumber	32222-06-3
gptkbp:chemicalFormula	C27H44O3
gptkbp:contraindication	gptkb:hypercalcemia vitamin D toxicity
gptkbp:discoveredIn	1971
gptkbp:eliminationHalfLife	5-8 hours
gptkbp:excretion	urine
gptkbp:foundIn	humans other vertebrates
https://www.w3.org/2000/01/rdf-schema#label	Calcitriol
gptkbp:increasesAbsorptionOf	calcium phosphate
gptkbp:inhibitedBy	parathyroid hormone secretion
gptkbp:IUPACName	(1R,3S,5Z,7E,22E)-9,10-secocholesta-5,7,10(19),22-tetraene-1,3,25-triol
gptkbp:KEGGID	D00279
gptkbp:legalStatus	prescription only
gptkbp:meltingPoint	120 °C
gptkbp:MeSH_ID	D017382
gptkbp:metabolism	liver
gptkbp:molecularWeight	416.64 g/mol
gptkbp:otherName	gptkb:1,25-dihydroxyvitamin_D3 gptkb:Rocaltrol gptkb:Calcijex 1,25(OH)2D3
gptkbp:predecessor	gptkb:25-hydroxyvitamin_D3
gptkbp:pregnancyCategory	C (US)
gptkbp:producedBy	gptkb:kidney
gptkbp:PubChem_CID	5280453 CHEMBL1204 DB00136
gptkbp:recipient	vitamin D receptor
gptkbp:regulates	calcium homeostasis phosphate homeostasis
gptkbp:routeOfAdministration	oral topical intravenous
gptkbp:sideEffect	gptkb:hypercalcemia nausea vomiting headache weakness hyperphosphatemia
gptkbp:UNII	FXC9231JVH
gptkbp:usedFor	gptkb:bone gptkb:secondary_hyperparathyroidism psoriasis chronic kidney disease hypocalcemia
gptkbp:bfsParent	gptkb:Cholesterol gptkb:Kidneys
gptkbp:bfsLayer	6