Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activity |
ATP-dependent
electrogenic antiport |
| gptkbp:alsoKnownAs |
calcium ATPase
|
| gptkbp:catalyzes |
hydrolysis of ATP
|
| gptkbp:discoveredBy |
Setsuro Ebashi
|
| gptkbp:discoveredIn |
1963
|
| gptkbp:EC_number |
3.6.3.8
|
| gptkbp:encodedBy |
ATP2A2
ATP2A1 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 |
| gptkbp:family |
P-type ATPase family
|
| gptkbp:foundIn |
gptkb:endoplasmic_reticulum
gptkb:plasma_membrane sarcoplasmic reticulum |
| gptkbp:function |
transports calcium ions across membranes
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ca2+ ATPase
|
| gptkbp:importantFor |
enables muscle relaxation
prevents cytotoxicity removes Ca2+ from cytosol |
| gptkbp:inhibitedBy |
thapsigargin
|
| gptkbp:locale |
gptkb:cell_membrane
|
| gptkbp:mechanismOfAction |
P-type ATPase
|
| gptkbp:mutationAssociatedWith |
Darier disease
Brody disease |
| gptkbp:regulates |
gptkb:phospholamban
sarcolipin |
| gptkbp:requires |
gptkb:ATP
neuronal signaling cardiac muscle function skeletal muscle function |
| gptkbp:role |
muscle relaxation
calcium homeostasis |
| gptkbp:structure |
transmembrane domains
actuator domain nucleotide binding domain phosphorylation domain |
| gptkbp:subspecies |
gptkb:SPCA
PMCA SERCA |
| gptkbp:bfsParent |
gptkb:CHEBI:28009
gptkb:CHEBI:15765 |
| gptkbp:bfsLayer |
7
|