CHEMBL31808

GPTKB entity

Statements (40)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:approvalYear 2012
gptkbp:ATCCode gptkb:L01XX43
gptkbp:bioavailability 31.8%
gptkbp:brand gptkb:Erivedge
gptkbp:CASNumber 879085-55-9
gptkbp:drugClass Hedgehog pathway inhibitor
gptkbp:eliminationHalfLife 4 days
gptkbp:hasFirstInClass yes
gptkbp:hasInChIKey YMGUEVCWXUQGLM-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C17H19N3O3S
gptkbp:hasOrphanDrugStatus yes
gptkbp:hasPatentExpiry 2028
gptkbp:hasSMILES CS(=O)(=O)C1=CC(=C(C=C1)Cl)NC(=O)C2=CC(=C(C=C2)Cl)C3=CC=CC=N3
gptkbp:hasUNII 6HG8UB2MUY
https://www.w3.org/2000/01/rdf-schema#label CHEMBL31808
gptkbp:indication treatment of basal cell carcinoma
gptkbp:IUPACName 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Genentech
gptkbp:mechanismOfAction Smoothened antagonist
gptkbp:molecularWeight 345.42
gptkbp:pregnancyCategory D (US)
gptkbp:proteinBinding >99%
gptkbp:PubChem_CID gptkb:CHEMBL31808
DB08816
24776440
gptkbp:routeOfAdministration oral
gptkbp:sideEffect fatigue
weight loss
alopecia
dysgeusia
muscle spasms
gptkbp:status approved
gptkbp:synonym gptkb:GDC-0449
Vismodegib
gptkbp:target gptkb:Smoothened_receptor
gptkbp:therapeuticArea oncology
gptkbp:bfsParent gptkb:myrcene
gptkbp:bfsLayer 6