Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
bacterial toxin
|
| gptkbp:alsoKnownAs |
Clostridium difficile toxins
|
| gptkbp:diagnosedBy |
detected by PCR
detected by immunoassay |
| gptkbp:effect |
induction of cell death
disruption of actin cytoskeleton |
| gptkbp:effectOnCells |
apoptosis
inflammation disruption of tight junctions |
| gptkbp:encodedBy |
tcdA gene
tcdB gene |
| https://www.w3.org/2000/01/rdf-schema#label |
C. difficile toxins
|
| gptkbp:includes |
gptkb:toxin_A
gptkb:toxin_B |
| gptkbp:locationOfGenes |
pathogenicity locus (PaLoc)
|
| gptkbp:mechanismOfAction |
glucosylation of Rho GTPases
|
| gptkbp:neutralizedBy |
antitoxin antibodies
|
| gptkbp:producedBy |
gptkb:Clostridioides_difficile
|
| gptkbp:role |
cause of antibiotic-associated diarrhea
cause of pseudomembranous colitis |
| gptkbp:studiedBy |
model for studying cytoskeletal disruption
|
| gptkbp:targetCellType |
intestinal epithelial cells
|
| gptkbp:toxinAType |
gptkb:enterotoxin
|
| gptkbp:toxinBType |
cytotoxin
|
| gptkbp:bfsParent |
gptkb:Clostridium_difficile_toxin_A/B
|
| gptkbp:bfsLayer |
8
|