Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
bacterial toxin
|
| gptkbp:alternativeName |
TcdB
|
| gptkbp:cause |
gptkb:pseudomembranous_colitis
diarrhea colonic inflammation |
| gptkbp:decommissioned |
neutralizing antibodies
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:effect |
induces cell death
disrupts actin cytoskeleton |
| gptkbp:gene |
tcdB
|
| https://www.w3.org/2000/01/rdf-schema#label |
toxin B
|
| gptkbp:mechanismOfAction |
glucosylates Rho GTPases
|
| gptkbp:molecularWeight |
~270 kDa
|
| gptkbp:producedBy |
gptkb:Clostridioides_difficile
|
| gptkbp:relatedToxin |
toxin A (TcdA)
|
| gptkbp:role |
major virulence factor in C. difficile infection
|
| gptkbp:structureType |
single polypeptide chain
|
| gptkbp:targetCellType |
intestinal epithelial cells
|
| gptkbp:toxicity |
mammalian cells
|
| gptkbp:usedIn |
diagnosis of C. difficile infection
|
| gptkbp:bfsParent |
gptkb:Clostridium_difficile_toxin_A/B
|
| gptkbp:bfsLayer |
8
|