| gptkbp:instanceOf | gptkb:mental_disorder gptkb:mood_disorder
 
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                                | gptkbp:canBeManagedBy | gptkb:psychotherapy gptkb:drug
 
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                                | gptkbp:class | gptkb:DSM-5 gptkb:ICD-10
 
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                                | gptkbp:complication | gptkb:substance_abuse suicide
 occupational impairment
 legal problems
 relationship difficulties
 
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                                | gptkbp:diagnosedBy | gptkb:DSM-5_criteria psychiatric evaluation
 
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                                | gptkbp:differentialDiagnosis | gptkb:Bipolar_II_disorder gptkb:major_depressive_disorder
 schizophrenia
 borderline personality disorder
 
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                                | gptkbp:firstDescribed | gptkb:Emil_Kraepelin 
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                                | gptkbp:hasDepressiveEpisodeDuration | at least 2 weeks 
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                                | gptkbp:hasManicEpisodeDuration | at least 7 days 
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                                | gptkbp:hasNoCure | true 
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                                | gptkbp:ICD-10_code | F31.1 
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                                | gptkbp:offersCourse | episodic chronic
 recurrent
 
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                                | gptkbp:onset | late adolescence to early adulthood 
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                                | gptkbp:partOf | bipolar spectrum 
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                                | gptkbp:prevalence | ~1% of population 
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                                | gptkbp:riskFactor | gptkb:substance_abuse genetic predisposition
 stressful life events
 family history of bipolar disorder
 
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                                | gptkbp:symptom | psychosis increased energy
 insomnia
 suicidal ideation
 irritability
 impulsivity
 decreased need for sleep
 grandiosity
 racing thoughts
 depressive episode
 manic episode
 
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                                | gptkbp:treatment | gptkb:psychotherapy gptkb:carbamazepine
 lithium
 antipsychotics
 electroconvulsive therapy
 mood stabilizers
 valproate
 
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                                | gptkbp:bfsParent | gptkb:Bipolar_disorder 
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                                | gptkbp:bfsLayer | 7 
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                                | https://www.w3.org/2000/01/rdf-schema#label | Bipolar I disorder 
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