Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:administered_by |
intravenous injection
|
| gptkbp:approves |
gptkb:2018
gptkb:FDA |
| gptkbp:availability |
limited in some regions
|
| gptkbp:clinical_trial |
Phase III trials
|
| gptkbp:clinical_use |
emergency situations
|
| gptkbp:contraindication |
hypersensitivity to the drug
|
| gptkbp:developed_by |
gptkb:Portola_Pharmaceuticals
|
| gptkbp:dosage_form |
lyophilized powder
|
| gptkbp:duration |
as needed
|
| https://www.w3.org/2000/01/rdf-schema#label |
Andexanet alfa
|
| gptkbp:indication |
patients on factor Xa inhibitors
|
| gptkbp:is_effective_against |
improves patient outcomes
reduces bleeding complications shown to be effective in trials used in life-threatening situations |
| gptkbp:is_monitored_by |
thromboembolic events
renal function bleeding complications |
| gptkbp:lifespan |
approximately 30 minutes
|
| gptkbp:marketed_as |
gptkb:Andexxa
|
| gptkbp:mechanism_of_action |
binds to factor Xa
|
| gptkbp:patient_education |
adherence to follow-up appointments
importance of reporting side effects recognizing signs of bleeding understanding anticoagulation therapy |
| gptkbp:patient_population |
adults
|
| gptkbp:pharmacokinetics |
reverses anticoagulation effects
rapid distribution |
| gptkbp:price |
high
|
| gptkbp:provides_guidance_on |
included in emergency protocols
|
| gptkbp:regulatory_compliance |
approved for use in Europe
approved for use in the US |
| gptkbp:related_products |
gptkb:rivaroxaban
gptkb:apixaban gptkb:edoxaban fondaparinux |
| gptkbp:research_focus |
cost-effectiveness analysis
patient-reported outcomes long-term outcomes safety profile comparative effectiveness dosing strategies |
| gptkbp:research_status |
ongoing studies
|
| gptkbp:rounds |
renal
|
| gptkbp:route_of_administration |
IV bolus followed by infusion
|
| gptkbp:side_effect |
fatigue
headache nausea thromboembolic events hypotension infusion site reactions |
| gptkbp:storage |
refrigerated
|
| gptkbp:used_for |
reversal of anticoagulation
|
| gptkbp:bfsParent |
gptkb:rivaroxaban
|
| gptkbp:bfsLayer |
6
|