Aconitine

URI: https://gptkb.org/entity/Aconitine

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:Dragon gptkb:chemical_compound alkaloid
gptkbp:antidote	no specific antidote
gptkbp:CASNumber	302-27-2
gptkbp:category	diterpenoid alkaloid
gptkbp:chemicalFormula	C34H47NO11
gptkbp:discoveredBy	gptkb:Geiger_and_Hesse
gptkbp:discoveredIn	1833
gptkbp:effect	gptkb:Dragon gptkb:cardiotoxin
gptkbp:foundIn	gptkb:monkshood gptkb:Aconitum_plants wolfsbane
https://www.w3.org/2000/01/rdf-schema#label	Aconitine
gptkbp:IUPACName	(1α,3α,6α,14α,16β)-20-ethyl-3,13,15-trihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-8,14,18-trione
gptkbp:LD50	1-2 mg/kg (oral, mice)
gptkbp:mechanismOfAction	modifies sodium channel function
gptkbp:meltingPoint	199–200 °C
gptkbp:molecularWeight	645.75 g/mol
gptkbp:origin	gptkb:Aconitum_napellus gptkb:Aconitum_carmichaelii
gptkbp:PubChem_CID	245004
gptkbp:sideEffect	gptkb:arrhythmia nausea vomiting diarrhea tingling death (in high doses)
gptkbp:solubility	slightly soluble in water soluble in alcohol
gptkbp:toxicity	highly toxic
gptkbp:treatment	supportive care antiarrhythmic drugs activated charcoal (if early)
gptkbp:uses	historically used as poison used in traditional medicine (with risk)
gptkbp:bfsParent	gptkb:Wolfsbane
gptkbp:bfsLayer	5