|
gptkbp:instanceOf
|
gptkb:drug
antidote
mucolytic agent
|
|
gptkbp:approvalYear
|
1960s
|
|
gptkbp:approvedBy
|
gptkb:Italy
|
|
gptkbp:ATCCode
|
gptkb:R05CB01
|
|
gptkbp:CASNumber
|
616-91-1
|
|
gptkbp:category
|
antioxidant
amino acid derivative
expectorant
|
|
gptkbp:chemicalFormula
|
C5H9NO3S
|
|
gptkbp:contraindication
|
hypersensitivity to acetylcysteine
|
|
gptkbp:discoveredBy
|
gptkb:F._Cavallini
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:eliminationHalfLife
|
5.6 hours (oral)
6.25 hours (IV)
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Acetylcysteine
|
|
gptkbp:IUPACName
|
(2R)-2-acetamido-3-sulfanylpropanoic acid
|
|
gptkbp:KEGGID
|
gptkb:D00221
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
breaks disulfide bonds in mucus
increases glutathione levels
|
|
gptkbp:meltingPoint
|
109°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
163.2 g/mol
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:DB06151
gptkb:CHEMBL1048
12035
11546
|
|
gptkbp:routeOfAdministration
|
oral
inhalation
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
rash
anaphylactoid reactions
|
|
gptkbp:solubility
|
freely soluble
|
|
gptkbp:synonym
|
gptkb:N-acetylcysteine
gptkb:NAC
|
|
gptkbp:UNII
|
WYQ7N0BPYC
|
|
gptkbp:usedFor
|
chronic obstructive pulmonary disease
cystic fibrosis
paracetamol overdose
prevention of contrast-induced nephropathy
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:N-acetylcysteine
|
|
gptkbp:bfsLayer
|
6
|