Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
5-aminolevulinate synthase
ALAS |
| gptkbp:catalyzes |
condensation of glycine and succinyl-CoA to form aminolevulinic acid (ALA)
|
| gptkbp:cofactor |
gptkb:pyridoxal_phosphate
|
| gptkbp:deficiencyCauses |
X-linked sideroblastic anemia
|
| gptkbp:EC_number |
2.3.1.37
|
| gptkbp:foundIn |
mitochondria
|
| gptkbp:fullName |
Aminolevulinic acid synthase
|
| gptkbp:gene |
gptkb:ALAS2
ALAS1 |
| gptkbp:hasIsoform |
ALAS1 (housekeeping)
ALAS2 (erythroid-specific) |
| https://www.w3.org/2000/01/rdf-schema#label |
ALA synthase
|
| gptkbp:organism |
animals
humans |
| gptkbp:pathway |
heme biosynthesis
|
| gptkbp:rateLimitingStepOf |
heme synthesis
|
| gptkbp:regulates |
heme (feedback inhibition)
|
| gptkbp:bfsParent |
gptkb:P5P
|
| gptkbp:bfsLayer |
8
|