Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
cardiovascular diseases
lung diseases kidney diseases |
| gptkbp:clinical_trial |
ongoing studies
biomarker for acute kidney injury biomarker for chronic kidney disease biomarker for heart failure biomarker for sepsis |
| gptkbp:clinical_use |
biomarker for diseases
|
| gptkbp:discovery_year |
gptkb:1980s
|
| gptkbp:field_of_study |
biochemistry
|
| gptkbp:function |
binds to free hemoglobin
involved in inflammation response protects against oxidative stress |
| gptkbp:genetic_studies |
affects protein function
|
| https://www.w3.org/2000/01/rdf-schema#label |
A1 M
|
| gptkbp:initiated_by |
hemoglobin-induced toxicity
|
| gptkbp:interacts_with |
free radicals
hemoglobin other plasma proteins |
| gptkbp:is_expressed_in |
liver
|
| gptkbp:location |
found in human plasma
|
| gptkbp:pathway |
cellular stress response
inflammatory response antioxidant defense |
| gptkbp:promoter |
gptkb:A1_M_gene
|
| gptkbp:research_areas |
neuroprotection
anti-inflammatory effects antioxidant effects |
| gptkbp:research_focus |
molecular biology
cell signaling clinical trials biomedical research therapeutic strategies cardiovascular health kidney function therapeutic uses protein structure disease mechanisms clinical applications protein interactions lung function inflammatory pathways biomarker development oxidative stress mechanisms |
| gptkbp:structure |
monomeric protein
|
| gptkbp:therapeutic_application |
potential treatment for ischemia
potential treatment for neurodegenerative diseases potential treatment for stroke |
| gptkbp:weight |
approximately 26 k Da
|
| gptkbp:bfsParent |
gptkb:The_A60_Road
|
| gptkbp:bfsLayer |
6
|