|
gptkbp:instanceOf
|
gptkb:chemical_compound
|
|
gptkbp:approvedBy
|
2003
|
|
gptkbp:ATCCode
|
gptkb:C10AA07
|
|
gptkbp:bioavailability
|
20% (oral)
|
|
gptkbp:CASNumber
|
gptkb:156547-39-8
|
|
gptkbp:contraindication
|
gptkb:liver_disease
pregnancy
breastfeeding
|
|
gptkbp:eliminationHalfLife
|
19 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
C22H28FN3O6S
|
|
gptkbp:hasSMILES
|
CC(C)C1=NC(=C(C(=N1)N(C)S(=O)(=O)C)C2=CC=C(C=C2)F)C/C=C(/C(=O)O)C(C)O
|
|
gptkbp:hasUNII
|
2C3O6ZLU3M
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
156547-39-8
|
|
gptkbp:IUPACName
|
gptkb:(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic_acid
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:AstraZeneca
|
|
gptkbp:marketedAs
|
gptkb:Crestor
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:meltingPoint
|
122-125 °C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
481.54 g/mol
|
|
gptkbp:name
|
gptkb:rosuvastatin
|
|
gptkbp:proteinBinding
|
88%
|
|
gptkbp:PubChem_CID
|
gptkb:DB01098
CHEMBL121
446157
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
headache
muscle pain
|
|
gptkbp:usedFor
|
prevention of cardiovascular disease
statin
lipid-lowering agent
treatment of hypercholesterolemia
|
|
gptkbp:bfsParent
|
gptkb:BeneFIX
|
|
gptkbp:bfsLayer
|
6
|