Triple
T32226586
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | irinotecan |
E823218
|
entity |
| Predicate | instanceOf |
P0
|
FINISHED |
| Object | camptothecin derivative |
C59323
|
CONCEPT FINISHED |
How this triple was built (1 step)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
CD
Concept disambiguation
gpt-5-mini-2025-08-07
Target class: camptothecin derivative Context triple: [irinotecan, instanceOf, camptothecin derivative]
-
A.
topoisomerase I inhibitor
chosen
A topoisomerase I inhibitor is a drug that blocks the activity of the topoisomerase I enzyme, preventing DNA strand relaxation during replication and transcription and thereby inducing DNA damage and cell death, particularly in rapidly dividing cells.
-
B.
topoisomerase II inhibitor
A topoisomerase II inhibitor is a drug that interferes with the topoisomerase II enzyme’s ability to manage DNA topology, thereby inducing DNA strand breaks and inhibiting cell replication, particularly in rapidly dividing cancer cells.
-
C.
nitrogen mustard derivative
A nitrogen mustard derivative is a chemical compound structurally related to nitrogen mustards, typically designed to act as an alkylating agent that can modify DNA or other biomolecules, often used in chemotherapy or as a research tool.
-
D.
PARP inhibitor
A PARP inhibitor is a targeted anticancer drug that blocks poly(ADP-ribose) polymerase enzymes to prevent DNA repair in tumor cells, leading to their death, particularly in cancers with existing DNA repair defects such as BRCA-mutated tumors.
-
E.
cancer drug
A cancer drug is a therapeutic agent specifically designed to prevent, slow, or eliminate the growth and spread of cancer cells in the body.
- F. None of above.
Provenance (1 batch)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69f3490b4f948190b99e4f999f5be25f |
completed | April 30, 2026, 12:20 p.m. |
Created at: May 1, 2026, 12:38 a.m.