|
gptkbp:instanceOf
|
gptkb:drug
gptkb:anticoagulant
|
|
gptkbp:administeredBy
|
subcutaneous injection
intravenous injection
|
|
gptkbp:antidote
|
gptkb:protamine_sulfate
|
|
gptkbp:ATCCode
|
gptkb:B01AB01
|
|
gptkbp:contraindication
|
active bleeding
history of heparin-induced thrombocytopenia
severe thrombocytopenia
|
|
gptkbp:derivedFrom
|
bovine lung
porcine intestinal mucosa
|
|
gptkbp:discoveredBy
|
gptkb:Jay_McLean
|
|
gptkbp:discoveredIn
|
1916
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
unfractionated heparin
|
|
gptkbp:includedIn
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits factor Xa
inhibits thrombin
|
|
gptkbp:molecularWeight
|
3,000 to 30,000 Da
|
|
gptkbp:monitors
|
gptkb:activated_partial_thromboplastin_time_(aPTT)
|
|
gptkbp:notGivenBy
|
oral route
|
|
gptkbp:pregnancyCategory
|
safe in pregnancy
|
|
gptkbp:relatedTo
|
low molecular weight heparin
|
|
gptkbp:routeOfAdministration
|
subcutaneous
intravenous
|
|
gptkbp:sideEffect
|
gptkb:heparin-induced_thrombocytopenia
bleeding
osteoporosis (with long-term use)
|
|
gptkbp:usedFor
|
prevention of blood clots
prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
|
|
gptkbp:bfsParent
|
gptkb:heparin-induced_thrombocytopenia
|
|
gptkbp:bfsLayer
|
7
|