tizanidine

GPTKB entity

Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:drug
muscle relaxant
gptkbp:approvedBy 1996 (US)
gptkbp:ATCCode gptkb:M03BX02
gptkbp:availableOn gptkb:tablet
capsule
gptkbp:brand gptkb:Sirdalud
gptkb:Zanaflex
gptkbp:CASNumber 51322-75-9
gptkbp:category centrally acting muscle relaxant
imidazoline derivative
gptkbp:chemicalFormula C9H8ClN5S
gptkbp:contraindication severe liver impairment
concomitant use with ciprofloxacin
concomitant use with fluvoxamine
gptkbp:discoveredBy gptkb:Sandoz
gptkbp:eliminationHalfLife 2.5 hours
https://www.w3.org/2000/01/rdf-schema#label tizanidine
gptkbp:interactsWith gptkb:beer
CYP1A2 inhibitors
oral contraceptives
antihypertensive drugs
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction alpha-2 adrenergic agonist
gptkbp:metabolism liver
gptkbp:origin gptkb:Switzerland
gptkbp:patentExpired Yes
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID 5487
DB00697
gptkbp:routeOfAdministration oral
gptkbp:sideEffect dizziness
drowsiness
hypotension
dry mouth
liver dysfunction
weakness
gptkbp:UNII 6ZDQ3P0S1W
gptkbp:usedFor multiple sclerosis
spinal cord injury
muscle spasticity
gptkbp:bfsParent gptkb:Muscle_Relaxants,_Central
gptkbp:bfsLayer 7