|
gptkbp:instanceOf
|
gptkb:drug
beta blocker
|
|
gptkbp:approvedBy
|
1978
|
|
gptkbp:ATCCode
|
C07AA06
|
|
gptkbp:bioavailability
|
61%
|
|
gptkbp:brand
|
gptkb:Betimol
gptkb:Blocadren
gptkb:Istalol
gptkb:Timoptic
|
|
gptkbp:CASNumber
|
26839-75-8
|
|
gptkbp:contraindication
|
asthma
sinus bradycardia
severe COPD
second or third degree heart block
|
|
gptkbp:discoveredBy
|
gptkb:Merck
|
|
gptkbp:drugClass
|
non-selective beta blocker
|
|
gptkbp:eliminationHalfLife
|
4-5 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C13H24N4O3S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
timolol
|
|
gptkbp:IUPACName
|
(S)-1-tert-butylamino-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
beta-adrenergic receptor antagonist
|
|
gptkbp:meltingPoint
|
202-204°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
60%
|
|
gptkbp:PubChem_CID
|
33624
CHEMBL1201
31013
|
|
gptkbp:routeOfAdministration
|
oral
topical (eye drops)
|
|
gptkbp:sideEffect
|
fatigue
hypotension
bradycardia
bronchospasm
|
|
gptkbp:synonym
|
gptkb:timolol_maleate
|
|
gptkbp:UNII
|
5JKY92S7BR
|
|
gptkbp:usedFor
|
myocardial infarction
hypertension
angina
glaucoma
migraine prophylaxis
ocular hypertension
|
|
gptkbp:bfsParent
|
gptkb:Cosopt
gptkb:Timoptic
|
|
gptkbp:bfsLayer
|
5
|