|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:antibiotic
|
|
gptkbp:affiliatedWith
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:approvedForMedicalUse
|
1968
|
|
gptkbp:ATCCode
|
J04AB
|
|
gptkbp:CASNumber
|
14897-39-3
|
|
gptkbp:chemicalFormula
|
C37H47NO12
|
|
gptkbp:contraindication
|
severe liver disease
|
|
gptkbp:discoveredBy
|
gptkb:Piero_Sensi
gptkb:Maria_Teresa_Timbal
Gabriele Maga
Francesco Parenti
Giovanni Lancini
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:drugClass
|
ansamycin
|
|
gptkbp:effect
|
gptkb:Mycobacterium_tuberculosis
Gram-negative bacteria
Gram-positive bacteria
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:firstIsolatedFrom
|
soil sample from France
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial DNA-dependent RNA polymerase
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
693.77 g/mol
|
|
gptkbp:notableDerivative
|
gptkb:Streptomyces_mediterranei
|
|
gptkbp:origin
|
natural product
|
|
gptkbp:patent
|
1957
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:producedBy
|
gptkb:Amycolatopsis_mediterranei
|
|
gptkbp:relatedTo
|
gptkb:rifampicin
gptkb:rifaximin
gptkb:rifabutin
rifapentine
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
hepatotoxicity
allergic reactions
gastrointestinal upset
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:usedFor
|
treatment of tuberculosis
treatment of leprosy
treatment of mycobacterial infections
|
|
gptkbp:bfsParent
|
gptkb:Streptomyces_mediterranei
|
|
gptkbp:bfsLayer
|
6
|