remdesivir

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf antiviral drug
nucleotide
gptkbp:administeredBy gptkb:physician
dextrose
saline
gptkbp:approvedBy gptkb:European_Union
gptkb:India
gptkb:Japan
gptkb:United_States
gptkb:FDA
2020
gptkbp:ATCCode J05AB16
gptkbp:CASNumber 1809249-37-3
gptkbp:chemicalFormula C27H35N6O8P
gptkbp:clinicalTrialPhase gptkb:ACTT-1
gptkb:Solidarity_trial_(WHO)
gptkbp:contraindication severe renal impairment
hypersensitivity to remdesivir
gptkbp:cost approximately $2,340 per course (US, 2020)
gptkbp:developedBy gptkb:Gilead_Sciences
gptkbp:discoveredIn 2009
gptkbp:effectOnCOVID19 no significant reduction in mortality (per some studies)
shortens recovery time in some patients
gptkbp:eliminationHalfLife 1 hour (remdesivir), 25 hours (GS-441524 metabolite)
gptkbp:emergencyServices granted by FDA (2020)
gptkbp:excretion kidneys
gptkbp:form solution for injection
lyophilized powder
gptkbp:genericAvailable yes (in some countries)
https://www.w3.org/2000/01/rdf-schema#label remdesivir
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits viral RNA-dependent RNA polymerase
gptkbp:metabolism gptkb:GS-441524
liver
gptkbp:molecularWeight 602.6 g/mol
gptkbp:notOrallyBioavailable true
gptkbp:notRecommendedFor children under 12 years (in some regions)
gptkbp:patent gptkb:Gilead_Sciences
gptkbp:pregnancyCategory Not assigned (US)
gptkbp:PubChem_CID 121304016
DB14761
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
elevated liver enzymes
allergic reactions
gptkbp:storage refrigerated
gptkbp:synonym gptkb:GS-5734
gptkbp:UNII R7XA6E0Z1L
gptkbp:usedFor gptkb:COVID-19
gptkb:Ebola_virus_disease_(investigational)
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:COVID-19
gptkb:COVID-19_pandemic
gptkbp:bfsLayer 4