Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:infrastructure_project
|
| gptkbp:activities |
catalyzes RNA synthesis
synthesizes rRNA and tRNA |
| gptkbp:associated_with |
sigma factors
transcriptional pausing RNA_polymerase_II_in_eukaryotes |
| gptkbp:can_be |
regulated by small RNAs
|
| gptkbp:composedOf |
beta and beta' subunits
|
| gptkbp:disbanded |
involves hairpin loop formation
|
| gptkbp:endOfProduction |
involves specific sequences
|
| gptkbp:evaluates |
elongation_of_RNA_chain
|
| gptkbp:function |
synthesizes RNA from a DNA template
transcribes DNA into RNA |
| gptkbp:has_a_focus_on |
evolutionary studies
biotechnology research |
| https://www.w3.org/2000/01/rdf-schema#label |
prokaryotic RNA polymerase
|
| gptkbp:influenced |
cell growth conditions
nucleotide availability |
| gptkbp:interactsWith |
transcription factors
|
| gptkbp:is_a_key_component_of |
the transcription machinery
|
| gptkbp:is_a_key_player_in |
gene regulation
|
| gptkbp:is_a_subject_of |
biochemical studies
|
| gptkbp:is_available_in |
bacteria
|
| gptkbp:is_essential_for |
protein synthesis
cell survival RNA synthesis during transcription the life cycle of bacteria. viral replication in some cases |
| gptkbp:is_governed_by |
feedback mechanisms
|
| gptkbp:is_involved_in |
chromatin remodeling
gene expression mRNA processing transcriptional activation cellular response to stress horizontal gene transfer DNA repair processes cellular differentiation processes response to environmental changes antigenic variation in pathogens operon regulation pathogen virulence mechanisms |
| gptkbp:is_studied_in |
molecular biology
its evolutionary significance its role in antibiotic resistance |
| gptkbp:isActiveIn |
rifampicin
|
| gptkbp:location |
found in prokaryotic cells
|
| gptkbp:members |
composed of multiple subunits
|
| gptkbp:produces |
primary transcript
|
| gptkbp:products |
gptkb:mRNA
|
| gptkbp:relatedTo |
eukaryotic RNA polymerase
|
| gptkbp:requires |
nucleotide triphosphates
promoter sequences Mg2+ ions DNA strand separation |
| gptkbp:role |
transcription initiation
|
| gptkbp:sensors |
sensitive to certain antibiotics
|
| gptkbp:structureType |
core enzyme and sigma factor
|
| gptkbp:targets |
antibiotic development
novel therapeutic strategies genetic engineering applications |
| gptkbp:triggerType |
template-directed synthesis
|
| gptkbp:type |
multi-subunit enzyme
|
| gptkbp:was_a_factor_in |
cellular metabolism
|