|
gptkbp:instanceOf
|
gptkb:drug
antisense oligonucleotide
|
|
gptkbp:administeredBy
|
gptkb:physician
|
|
gptkbp:approvalYear
|
2016
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
|
gptkbp:ATCCode
|
gptkb:M09AX07
|
|
gptkbp:brand
|
gptkb:Spinraza
|
|
gptkbp:CASNumber
|
1258984-36-9
|
|
gptkbp:chemicalFormula
|
C234H323N61O128P17S17
|
|
gptkbp:cost
|
high
|
|
gptkbp:developer
|
gptkb:Biogen
gptkb:Ionis_Pharmaceuticals
|
|
gptkbp:firstApprovedCountry
|
gptkb:United_States
|
|
gptkbp:firstBook
|
yes
|
|
gptkbp:halfLife
|
135-177 days (CSF)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
nusinersen
|
|
gptkbp:indication
|
gptkb:5q_spinal_muscular_atrophy
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
gptkb:SMN2_gene_splicing_modifier
|
|
gptkbp:molecularWeight
|
7500 g/mol
|
|
gptkbp:orphanDrugStatus
|
yes
|
|
gptkbp:patent
|
gptkb:Biogen
|
|
gptkbp:pregnancyCategory
|
unknown
|
|
gptkbp:routeOfAdministration
|
intrathecal
|
|
gptkbp:sideEffect
|
respiratory infection
constipation
headache
back pain
|
|
gptkbp:storage
|
refrigerated
|
|
gptkbp:UNII
|
6F4BOG7O1H
|
|
gptkbp:usedFor
|
spinal muscular atrophy
|
|
gptkbp:bfsParent
|
gptkb:Spinal_muscular_atrophy
gptkb:Spinraza
gptkb:Spinal_Muscular_Atrophy
|
|
gptkbp:bfsLayer
|
6
|