mitochondrial theory of aging
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
scientific theory
|
| gptkbp:criticizedFor |
incomplete explanation of all aging processes
|
| gptkbp:field |
biogerontology
|
| https://www.w3.org/2000/01/rdf-schema#label |
mitochondrial theory of aging
|
| gptkbp:implies |
mitochondrial DNA deletions
mitochondrial DNA point mutations mitochondrial dysfunction in age-related diseases |
| gptkbp:influenced |
research on antioxidants
studies on mitochondrial biogenesis |
| gptkbp:originatedIn |
gptkb:Denham_Harman
|
| gptkbp:proposedBy |
impaired energy production in aging cells
mitochondrial DNA mutations accumulate with age mitochondrial dysfunction leads to cellular aging reactive oxygen species damage mitochondrial DNA aging is caused by accumulation of mitochondrial DNA damage |
| gptkbp:relatedTo |
gptkb:free_radical_theory_of_aging
neurodegenerative diseases cellular senescence oxidative stress |
| gptkbp:studiedIn |
model organisms such as mice and C. elegans
|
| gptkbp:yearProposed |
1972
|
| gptkbp:bfsParent |
gptkb:telomere_theory_of_aging
gptkb:free_radical_theory |
| gptkbp:bfsLayer |
7
|