|
gptkbp:instanceOf
|
gptkb:drug
vasopressor
|
|
gptkbp:administeredBy
|
hydrochloride salt
|
|
gptkbp:approvalYear
|
1996
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
C01CA17
|
|
gptkbp:bioavailability
|
93%
|
|
gptkbp:boxedWarningFor
|
supine hypertension
|
|
gptkbp:brand
|
Gutron
ProAmatine
|
|
gptkbp:CASNumber
|
42794-76-3
|
|
gptkbp:category
|
sympathomimetic agent
|
|
gptkbp:chemicalClass
|
gptkb:phenylethanolamine
|
|
gptkbp:contraindication
|
gptkb:pheochromocytoma
urinary retention
acute renal disease
severe organic heart disease
|
|
gptkbp:developedBy
|
Robugen
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:eliminationHalfLife
|
3-4 hours
|
|
gptkbp:excretion
|
kidneys
|
|
gptkbp:hasBoxedWarning
|
yes
|
|
gptkbp:hasMolecularFormula
|
C12H18N2O4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
midodrine
|
|
gptkbp:improves
|
blood pressure
|
|
gptkbp:KEGGID
|
D00441
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
alpha-1 adrenergic receptor agonist
|
|
gptkbp:MeSH_ID
|
D019821
|
|
gptkbp:metabolism
|
desglymidodrine
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prodrugOf
|
desglymidodrine
|
|
gptkbp:proteinBinding
|
less than 30%
|
|
gptkbp:PubChem_CID
|
4050
4195
CHEMBL1201
DB00211
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
pruritus
urinary retention
piloerection
supine hypertension
|
|
gptkbp:synonym
|
N-(2,5-dimethoxy-4-hydroxyphenyl)-2-glycinamidoethanamine
|
|
gptkbp:UNII
|
K2J09EMJ0B
|
|
gptkbp:usedFor
|
gptkb:orthostatic_hypotension
autonomic dysfunction
|
|
gptkbp:bfsParent
|
gptkb:orthostatic_hypotension
|
|
gptkbp:bfsLayer
|
6
|