|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:administered_by
|
gptkb:cream
|
|
gptkbp:approves
|
gptkb:2016
gptkb:FDA
|
|
gptkbp:bioavailability
|
gptkb:unknown
|
|
gptkbp:chemical_formula
|
C22 H25 Cl N2 O4 S
|
|
gptkbp:class
|
ophthalmic agents
|
|
gptkbp:clinical_trial
|
Phase III
ongoing for other indications
positive efficacy
|
|
gptkbp:clinical_use
|
treatment of dry eye
|
|
gptkbp:contraindication
|
hypersensitivity to lifitegrast
|
|
gptkbp:dosage_form
|
gptkb:Software_Solutions
|
|
gptkbp:drug_interactions
|
none significant reported
|
|
gptkbp:duration
|
as directed by physician
|
|
gptkbp:efficacy_studies
|
demonstrated improvement in symptoms
|
|
gptkbp:excretion
|
primarily in urine
|
|
gptkbp:feedback
|
generally positive
|
|
gptkbp:formulation
|
sterile solution
|
|
gptkbp:healthcare
|
gptkb:liquid
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lifitegrast
|
|
gptkbp:indication
|
ocular surface disease
|
|
gptkbp:ingredients
|
gptkb:lifitegrast
|
|
gptkbp:label
|
contains warnings
|
|
gptkbp:lifespan
|
gptkb:unknown
|
|
gptkbp:manufacturer
|
gptkb:Shire_Pharmaceuticals
|
|
gptkbp:market_position
|
available
|
|
gptkbp:marketed_as
|
gptkb:Xiidra
|
|
gptkbp:mechanism_of_action
|
integrin antagonist
|
|
gptkbp:metabolism
|
not extensively studied
|
|
gptkbp:packaging
|
single-use vials
|
|
gptkbp:patient_education
|
important for proper use
|
|
gptkbp:patient_population
|
adults
|
|
gptkbp:pharmacokinetics
|
not well understood
inhibits lymphocyte trafficking
|
|
gptkbp:price
|
varies by pharmacy
|
|
gptkbp:provides_guidance_on
|
included in treatment guidelines
follow prescribing information
|
|
gptkbp:regulatory_compliance
|
granted in 2016
|
|
gptkbp:requires
|
available
prescription only
|
|
gptkbp:research_focus
|
ocular diseases
|
|
gptkbp:route_of_administration
|
topical
|
|
gptkbp:safety_features
|
generally well tolerated
|
|
gptkbp:safety_measures
|
conducted in adults
|
|
gptkbp:service_frequency
|
twice daily
|
|
gptkbp:shelf_life
|
24 months
|
|
gptkbp:side_effect
|
headache
eye irritation
taste disturbance
conjunctival hyperemia
burning sensation in eyes
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:type_of_care
|
important for effectiveness
|
|
gptkbp:used_for
|
dry eye disease
|
|
gptkbp:bfsParent
|
gptkb:Xiidra
|
|
gptkbp:bfsLayer
|
6
|