isoflurane

GPTKB entity

Statements (57)
Predicate Object
gptkbp:instanceOf inhalational anesthetic
halogenated ether
gptkbp:approvalYear 1979
gptkbp:approvedBy gptkb:FDA
gptkbp:aroma mild, ether-like
gptkbp:ATCCode N01AB06
gptkbp:boilingPoint 48.5 °C
gptkbp:CASNumber 26675-46-7
gptkbp:color colorless
gptkbp:contraindication hypersensitivity
malignant hyperthermia susceptibility
gptkbp:countryOfOperation gptkb:Australia
gptkb:Canada
gptkb:United_Kingdom
gptkb:United_States
gptkbp:density 1.496 g/cm³
gptkbp:discoveredBy gptkb:Ross_Terrell
gptkbp:discoveredIn 1965
gptkbp:eliminationHalfLife 0.2 hours
gptkbp:excretion lungs
gptkbp:hasInChIKey DZLVTNWLSHSOFT-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C3H2ClF5O
gptkbp:hasSMILES CC(OC(F)(F)Cl)F
https://www.w3.org/2000/01/rdf-schema#label isoflurane
gptkbp:KEGGID D00419
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits NMDA receptor activity
potentiates GABA-A receptor activity
inhibits neuronal ion channels
gptkbp:meltingPoint -140 °C
gptkbp:metabolism minimal (0.2%)
gptkbp:minimumAlveolarConcentration 1.15% (in adults)
gptkbp:molecularWeight 184.5 g/mol
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID 3632
3763
CHEMBL1200697
DB00753
gptkbp:relatedTo gptkb:desflurane
gptkb:enflurane
sevoflurane
halothane
gptkbp:routeOfAdministration inhalation
gptkbp:sideEffect gptkb:arrhythmia
malignant hyperthermia
hypotension
respiratory depression
gptkbp:solubility slightly soluble in water
gptkbp:UNII CYS9AKD70P
gptkbp:usedFor general anesthesia
gptkbp:usedIn veterinary anesthesia
human anesthesia
gptkbp:vaporPressure 238 mmHg (at 20°C)
gptkbp:bfsParent gptkb:Halothane
gptkb:Norflurane
gptkb:Desflurane
gptkbp:bfsLayer 8