Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:activities |
effective against Aspergillus species
effective against Mucor species inhibits fungal lanosterol 14α-demethylase limited activity against Candida species |
| gptkbp:appointed_by |
intravenous infusion
oral tablet |
| gptkbp:approves |
gptkb:FDA
|
| gptkbp:availability |
available in many countries
|
| gptkbp:brand |
Cresemba
|
| gptkbp:clinical_trial |
studied in phase III trials
compared to voriconazole |
| gptkbp:contraindication |
not recommended in breastfeeding
not recommended in pregnancy concurrent use with strong CY P3 A4 inducers concurrent use with strong CY P3 A4 inhibitors hypersensitivity to isavuconazole |
| gptkbp:developed_by |
Basilea Pharmaceutica
|
| gptkbp:effective_date |
gptkb:2015
|
| gptkbp:formulation |
available as a capsule
available as a powder for injection |
| https://www.w3.org/2000/01/rdf-schema#label |
isavuconazole
|
| gptkbp:indication |
for patients with limited treatment options
|
| gptkbp:ingredients |
C24 H28 Cl N5 O4 S
|
| gptkbp:interacts_with |
may interact with statins
may interact with warfarin may interact with other antifungals |
| gptkbp:is_monitored_by |
requires monitoring of drug interactions
requires monitoring of liver function |
| gptkbp:is_used_for |
treatment of invasive aspergillosis
treatment of mucormycosis |
| gptkbp:lifespan |
approximately 130 hours
|
| gptkbp:manager |
IV
oral |
| gptkbp:pharmacokinetics |
highly protein-bound
metabolized by liver enzymes |
| gptkbp:price |
varies by region
|
| gptkbp:provides_information_on |
included in treatment guidelines for invasive fungal infections
|
| gptkbp:research |
ongoing studies for efficacy in other fungal infections
|
| gptkbp:rounds |
primarily through feces
some through urine |
| gptkbp:safety_features |
generally well tolerated
|
| gptkbp:side_effect |
headache
nausea vomiting diarrhea liver enzyme elevation infusion-related reactions |
| gptkbp:storage |
store at room temperature
protect from light |
| gptkbp:weight |
485.02 g/mol
|
| gptkbp:bfsParent |
gptkb:mucormycosis
|
| gptkbp:bfsLayer |
5
|