eltrombopag

GPTKB entity

Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:drug
small molecule
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2008
gptkbp:ATCCode gptkb:B02BX05
gptkbp:bioavailability 52%
gptkbp:brand gptkb:Promacta
gptkb:Revolade
gptkbp:CASNumber 496775-61-2
gptkbp:chemicalFormula biphenyl hydrazone derivative
gptkbp:contraindication severe hepatic impairment
gptkbp:developedBy GlaxoSmithKline
gptkbp:discoveredBy GlaxoSmithKline
gptkbp:drugClass thrombopoietin receptor agonist
gptkbp:eliminationHalfLife 21-32 hours
gptkbp:genericName no (as of 2024)
gptkbp:hasMolecularFormula C25H22N4O4
https://www.w3.org/2000/01/rdf-schema#label eltrombopag
gptkbp:KEGGID D08913
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction thrombopoietin receptor agonist
gptkbp:metabolism liver
gptkbp:molecularWeight 442.47 g/mol
gptkbp:patentExpired 2027
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 99%
gptkbp:PubChem_CID 9846183
CHEMBL1201736
DB06210
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
fatigue
headache
thromboembolic events
liver enzyme elevation
gptkbp:UNII Q1J0S2TZ4D
gptkbp:usedFor thrombocytopenia
chronic immune thrombocytopenia
severe aplastic anemia
thrombocytopenia in hepatitis C
gptkbp:bfsParent gptkb:Promacta
gptkb:Revolade
gptkbp:bfsLayer 5