Statements (19)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
small molecule
BET degrader |
| gptkbp:binds |
cereblon E3 ligase
|
| gptkbp:CASNumber |
1883548-89-7
|
| gptkbp:chemicalClass |
PROTAC
|
| gptkbp:developedBy |
James E. Bradner lab
|
| gptkbp:discoveredIn |
2015
|
| gptkbp:effect |
induces apoptosis in cancer cells
decreases c-MYC expression |
| https://www.w3.org/2000/01/rdf-schema#label |
dBET1
|
| gptkbp:mechanismOfAction |
induces proteasomal degradation of BET proteins
|
| gptkbp:publishedIn |
gptkb:Nature_Chemical_Biology
|
| gptkbp:target |
BRD4
BRD2 BRD3 |
| gptkbp:usedIn |
cancer research
epigenetics research |
| gptkbp:bfsParent |
gptkb:Targeted_Protein_Degradation
|
| gptkbp:bfsLayer |
8
|