Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:anthelmintic_drug
|
| gptkbp:administeredBy |
animals
humans |
| gptkbp:affiliatedWith |
gptkb:benzimidazole
|
| gptkbp:approvalYear |
1975
|
| gptkbp:ATCCode |
P02CA03
|
| gptkbp:bioavailability |
low (increased with fatty meal)
|
| gptkbp:brand |
gptkb:Zentel
gptkb:Albenza gptkb:Andazol gptkb:Eskazole gptkb:Valbazen |
| gptkbp:CASNumber |
54965-21-8
|
| gptkbp:chemicalFormula |
C12H15N3O2S
|
| gptkbp:contraindication |
gptkb:liver_disease
pregnancy |
| gptkbp:discoveredBy |
GlaxoSmithKline
|
| gptkbp:eliminationHalfLife |
8.5 hours
|
| gptkbp:excretion |
urine
bile feces |
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
binds to beta-tubulin
inhibits microtubule polymerization |
| gptkbp:metabolism |
liver
albendazole sulfone albendazole sulfoxide |
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:proteinBinding |
70%
|
| gptkbp:PubChem_CID |
2082
DB00518 |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
vomiting abdominal pain dizziness headache hair loss elevated liver enzymes bone marrow suppression |
| gptkbp:UNII |
F4216019LN
|
| gptkbp:usedFor |
treatment of strongyloidiasis
treatment of ascariasis treatment of cutaneous larva migrans treatment of filariasis treatment of giardiasis treatment of hookworm infection treatment of hydatid disease treatment of neurocysticercosis treatment of parasitic worm infestations treatment of pinworm infection treatment of toxocariasis treatment of trichuriasis |
| gptkbp:WHOModelListOfEssentialMedicines |
yes
|
| gptkbp:bfsParent |
gptkb:Evidence_Action's_Deworm_the_World_Initiative
gptkb:hookworm |
| gptkbp:bfsLayer |
6
|
| https://www.w3.org/2000/01/rdf-schema#label |
albendazole
|