|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
|
gptkbp:ATCCode
|
gptkb:N02CC
|
|
gptkbp:availableOn
|
gptkb:tablet
gptkb:Injection
Nasal spray
|
|
gptkbp:category
|
Antimigraine agents
|
|
gptkbp:contraindication
|
gptkb:Hemiplegic_migraine
gptkb:Coronary_artery_disease
gptkb:Basilar_migraine
History of stroke
Uncontrolled hypertension
|
|
gptkbp:developedBy
|
gptkb:Glaxo_(Sumatriptan)
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:effect
|
gptkb:Trigeminal_nerve
Cranial blood vessels
|
|
gptkbp:eliminationHalfLife
|
Varies by agent
|
|
gptkbp:example
|
gptkb:Almotriptan
gptkb:Eletriptan
gptkb:Frovatriptan
gptkb:Naratriptan
gptkb:Rizatriptan
gptkb:Sumatriptan
gptkb:Zolmitriptan
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Triptans
|
|
gptkbp:legalStatus
|
Prescription only
|
|
gptkbp:mechanismOfAction
|
Serotonin 5-HT1B/1D receptor agonist
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:notEffectiveAgainst
|
gptkb:Tension-type_headache
Prevention of migraine
|
|
gptkbp:notRecommendedFor
|
gptkb:MAO_inhibitors
gptkb:Ergotamine
|
|
gptkbp:pregnancyCategory
|
C (varies by country)
|
|
gptkbp:riskFactor
|
gptkb:Serotonin_syndrome
Medication overuse headache
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Nasal spray
Subcutaneous injection
|
|
gptkbp:sideEffect
|
gptkb:Nausea
Dizziness
Fatigue
Chest tightness
|
|
gptkbp:usedFor
|
Cluster headache treatment
Migraine treatment
|
|
gptkbp:bfsParent
|
gptkb:Cluster_headache
gptkb:Migraine
|
|
gptkbp:bfsLayer
|
6
|