Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:administered_by |
subcutaneous injection
|
| gptkbp:approves |
gptkb:European_Union
gptkb:United_States |
| gptkbp:class |
immunomodulator
|
| gptkbp:clinical_trial |
gptkb:DISCOVER-1
gptkb:DISCOVER-2 Phase 3 active psoriatic arthritis moderate to severe plaque psoriasis VOYAGE 1 VOYAGE 2 |
| gptkbp:contraindication |
hypersensitivity to guselkumab
|
| gptkbp:dosage_form |
solution for injection
|
| gptkbp:effective_date |
July 2017
|
| gptkbp:financial_support |
available for eligible patients
|
| gptkbp:formulation |
single-dose prefilled syringe
|
| gptkbp:frequency |
once every 8 weeks after initial doses
|
| https://www.w3.org/2000/01/rdf-schema#label |
Tremfya
|
| gptkbp:ingredients |
gptkb:guselkumab
|
| gptkbp:invention |
2027
|
| gptkbp:is_monitored_by |
allergic reactions
infections liver function tests |
| gptkbp:manufacturer |
gptkb:Janssen_Pharmaceuticals
|
| gptkbp:marketed_as |
gptkb:brand
|
| gptkbp:mechanism_of_action |
IL-23 inhibitor
|
| gptkbp:patient_population |
adults
children over 6 years old |
| gptkbp:pharmacokinetics |
reduces IL-23 levels
steady-state concentration achieved by week 16 |
| gptkbp:price |
varies by region
|
| gptkbp:provides_guidance_on |
recommended for certain patients with psoriasis
recommended for certain patients with psoriatic arthritis |
| gptkbp:regulatory_compliance |
approved by FDA
approved by EMA |
| gptkbp:requires |
available online
|
| gptkbp:research |
ongoing for other indications
|
| gptkbp:route_of_administration |
subcutaneous
|
| gptkbp:safety_measures |
risk of serious infections
risk of allergic reactions |
| gptkbp:sales |
available in multiple countries
|
| gptkbp:side_effect |
fatigue
headache thrombosis injection site reactions increased risk of malignancies |
| gptkbp:storage |
refrigerated
|
| gptkbp:type_of_care |
important for treatment efficacy
|
| gptkbp:type_of_insurance |
may vary by plan
|
| gptkbp:used_for |
treatment of psoriatic arthritis
treatment of plaque psoriasis |
| gptkbp:bfsParent |
gptkb:Eli_Lilly
|
| gptkbp:bfsLayer |
4
|